caa a22 4500 378892207 CHVBK 20180305123457.0 cr unu---uuuuu 161128e20040510xx s 000 0 eng 10.1515/CCLM.2004.095 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.095 Genetic analysis of glutathione S-transferase A1 and T1 polymorphisms in a Japanese population [Elektronische Daten] [Kumi Matsuno, Takahiro Kubota, Yuji Matsukura, Hiroshi Ishikawa, Tatsuji Iga] Novel allelic variants have been found in the glutathione S-transferase (GST) A1 and T1 genes. The former GSTA1*B allele is associated with low expression and the latter GSTT1*B allele lacks GSTT1 activity. The information on frequencies of both variants is poorly documented in the Japanese population. In this study we determined the frequencies of allelic variants of GSTA1 and GSTT1 in a Japanese population using PCR-restriction fragment length polymorphism and allele-specific PCR. The frequencies of GSTA1*B, GSTT1*0 and GSTT1*B alleles in the subjects were 16.0%, 71.1% and 0%, respectively. This is the first report on the frequencies of allelic variants of GSTA1 and GSTT1 in a Japanese population. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Matsuno Kumi aut Kubota Takahiro aut Matsukura Yuji aut Ishikawa Hiroshi aut Iga Tatsuji aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/5(2004-05-10), 560-562 1434-6621 42:5<560 2004 42 cclm https://doi.org/10.1515/CCLM.2004.095 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.095 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsuno Kumi aut NATIONALLICENCE 700 1- Kubota Takahiro aut NATIONALLICENCE 700 1- Matsukura Yuji aut NATIONALLICENCE 700 1- Ishikawa Hiroshi aut NATIONALLICENCE 700 1- Iga Tatsuji aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/5(2004-05-10), 560-562 1434-6621 42:5<560 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter