caa a22 4500 378892223 CHVBK 20180305123457.0 cr unu---uuuuu 161128e20040510xx s 000 0 eng 10.1515/CCLM.2004.082 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.082 The emerging value of P-selectin as a disease marker [Elektronische Daten] [János Kappelmayer, Béla Nagy, Kornél Miszti-Blasius, Zsuzsa Hevessy, Hendra Setiadi] Activated platelets are key components in many arterial disorders. P-selectin is an activation-dependent platelet receptor, which is also identified in endothelial cells. Together with E-and L-selectin it constitutes the selectin family. These transmembrane proteins have continued to attract great interest as they support rapid and reversible cell adhesion in flow systems and thus play an essential role in multicellular interactions during thrombosis and inflammation. Similarly to other lectins, selectins bind to different glycoconjugates with varying affinities. Protein ligands, equipped with the appropriate carbohydrate and sulfate moieties for P-selectin binding, have been identified in normal peripheral blood leukocytes and several non-hematopoietic organs, as well as on cancer cells. For diagnostic purposes, P-selectin can readily be detected on the platelet surface by flow cytometry and by ELISA as a soluble ligand in the plasma. Along with other markers, these data can be used in the assessment of platelet activation status. Such results bear clinical significance since P-selectin has been implicated in the pathogenesis of widespread disorders including coronary artery disease, stroke, diabetes and malignancy. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Kappelmayer János aut Nagy Béla aut Miszti-Blasius Kornél aut Hevessy Zsuzsa aut Setiadi Hendra aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/5(2004-05-10), 475-486 1434-6621 42:5<475 2004 42 cclm https://doi.org/10.1515/CCLM.2004.082 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.082 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kappelmayer János aut NATIONALLICENCE 700 1- Nagy Béla aut NATIONALLICENCE 700 1- Miszti-Blasius Kornél aut NATIONALLICENCE 700 1- Hevessy Zsuzsa aut NATIONALLICENCE 700 1- Setiadi Hendra aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/5(2004-05-10), 475-486 1434-6621 42:5<475 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter