Analysis of candidate genes in Polish families with obesity
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 378892274 | ||
| 003 | CHVBK | ||
| 005 | 20180305123457.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 161128e20040510xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1515/CCLM.2004.083 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.083 | ||
| 245 | 0 | 0 | |a Analysis of candidate genes in Polish families with obesity |h [Elektronische Daten] |c [Malgorzata Malczewska-Malec, Iwona Wybranska, Iwona Leszczynska-Golabek, Lukasz Partyka, Jadwiga Hartwich, Agata Jabrocka, Beata Kiec-Wilk, Malgorzata Kwasniak, Marcin Motyka, Aldona Dembinska-Kiec] |
| 520 | 3 |
|a This study analyzes the relationship between risk factors related to overweight/obesity, insulin resistance, lipid tolerance, hypertension, endothelial function and genetic polymorphisms associated with: i) appetite regulation (leptin, melanocortin-3-receptor (MCR-3), dopamine receptor 2 (D2R)); ii) adipocyte differentiation and insulin sensitivity (peroxisome proliferator-activated receptor-γ2 (PPAR-γ2), tumor necrosis factor-α (TNF-α)); iii) thermogenesis and free fatty acid (FFA) transport/catabolism (uncoupling protein-1 (UCP1), lipoprotein lipase (LPL), β2- and β3-adrenergic receptor (β2AR, β3AR), fatty acid transport protein-1 (FATP-1) and iv) lipoproteins (apoliprotein E (apoE), apo CIII). The 122 members of 40 obese Caucasian families from southern Poland participated in the study. The genotypes were analyzed by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) or by direct sequencing. Phenotypes related to obesity (body mass index (BMI), fat/lean body mass composition, waist-to-hip ratio (WHR)), fasting lipids, glucose, leptin and insulin, as well as insulin during oral glucose tolerance test (OGTT) (4 points within 2 hours) and during oral lipid tolerance test (OLTT) (5 points within 8 hours) were assessed. The insulin sensitivity indexes: homeostasis model assessment of insulin resistance, whole body insulin sensitivity index, hepatic insulin sensitivity and early secretory response to an oral glucose load (HOMA-IR, ISI-COMP, ISI-HOMA and DELTA) were calculated. The single gene mutations such as C105 T OB and Pro115 Gln PPAR-γ2 linked to morbid obesity were not detected in our group. A weak correlation between obesity and certain gene polymorphisms was observed. Being overweight (25 | |
| 540 | |a Copyright © 2004 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 700 | 1 | |a Malczewska-Malec |D Malgorzata |4 aut | |
| 700 | 1 | |a Wybranska |D Iwona |4 aut | |
| 700 | 1 | |a Leszczynska-Golabek |D Iwona |4 aut | |
| 700 | 1 | |a Partyka |D Lukasz |4 aut | |
| 700 | 1 | |a Hartwich |D Jadwiga |4 aut | |
| 700 | 1 | |a Jabrocka |D Agata |4 aut | |
| 700 | 1 | |a Kiec-Wilk |D Beata |4 aut | |
| 700 | 1 | |a Kwasniak |D Malgorzata |4 aut | |
| 700 | 1 | |a Motyka |D Marcin |4 aut | |
| 700 | 1 | |a Dembinska-Kiec |D Aldona |4 aut | |
| 773 | 0 | |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 42/5(2004-05-10), 487-493 |x 1434-6621 |q 42:5<487 |1 2004 |2 42 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2004.083 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2004.083 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Malczewska-Malec |D Malgorzata |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wybranska |D Iwona |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Leszczynska-Golabek |D Iwona |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Partyka |D Lukasz |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hartwich |D Jadwiga |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jabrocka |D Agata |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kiec-Wilk |D Beata |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kwasniak |D Malgorzata |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Motyka |D Marcin |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dembinska-Kiec |D Aldona |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemistry and Laboratory Medicine |d Walter de Gruyter |g 42/5(2004-05-10), 487-493 |x 1434-6621 |q 42:5<487 |1 2004 |2 42 |o cclm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||