St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro
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| 024 | 7 | 0 | |a 10.1515/BC.2004.155 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/BC.2004.155 | ||
| 245 | 0 | 0 | |a St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro |h [Elektronische Daten] |c [Christiana Winkler, Barbara Wirleitner, Katharina Schroecksnadel, Harald Schennach, Dietmar Fuchs] |
| 520 | 3 | |a St. John's wort (Hypericum perforatum) is an ancient folk remedy that has antiviral and antibacterial properties. Anti-inflammatory effects of the plant have been described and the application of H. perforatum extract as an effective antidepressant is well established. In this study we assayed the effect of H. perforatum extract on cytokine-induced tryptophan degradation in human peripheral blood mononuclear cells. Simultaneously, changes in the production of the immune activation marker neopterin were monitored. Both these biochemical pathways are triggered by interferon-γ. Our results show that extracts of H. perforatum strongly down-regulate mitogen-mediated tryptophan degradation in a dose-dependent manner. This effect seems to be based on a suppressive activity of H. perforatum on activated immunocompetent cells, resulting in a diminished production of interferon-γ. In line with this finding, neopterin synthesis was strongly down-regulated by the plant extract. Our results suggest that the reduction of tryptophan degradation by H. perforatum might be important in the action of the plant as an antidepressant. | |
| 540 | |a ©2004 by Walter de Gruyter Berlin New York | ||
| 690 | 7 | |a Biochemistry |2 nationallicence | |
| 690 | 7 | |a Molecular biology |2 nationallicence | |
| 690 | 7 | |a Cellular biology |2 nationallicence | |
| 690 | 7 | |a Hypericum perforatum |2 nationallicence | |
| 690 | 7 | |a immune activation |2 nationallicence | |
| 690 | 7 | |a indoleamine (2,3)-dioxygenase |2 nationallicence | |
| 690 | 7 | |a neopterin |2 nationallicence | |
| 690 | 7 | |a St. John's wort |2 nationallicence | |
| 690 | 7 | |a tryptophan |2 nationallicence | |
| 700 | 1 | |a Winkler |D Christiana |u Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A-6020 Innsbruck, Austria |4 aut | |
| 700 | 1 | |a Wirleitner |D Barbara |u Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A-6020 Innsbruck, Austria |4 aut | |
| 700 | 1 | |a Schroecksnadel |D Katharina |u Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A-6020 Innsbruck, Austria |4 aut | |
| 700 | 1 | |a Schennach |D Harald |u Central Institute of Blood Transfusion and Immunology, University Hospital Innsbruck, A-6020 Innsbruck, Austria |4 aut | |
| 700 | 1 | |a Fuchs |D Dietmar |u Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A-6020 Innsbruck, Austria and Ludwig Boltzmann Institute of AIDS-Research, A-6020 Innsbruck, Austria |4 aut | |
| 773 | 0 | |t Biological Chemistry |d Walter de Gruyter |g 385/12(2004-12-01), 1197-1202 |x 1431-6730 |q 385:12<1197 |1 2004 |2 385 |o bchm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/BC.2004.155 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/BC.2004.155 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Winkler |D Christiana |u Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A-6020 Innsbruck, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wirleitner |D Barbara |u Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A-6020 Innsbruck, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schroecksnadel |D Katharina |u Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A-6020 Innsbruck, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schennach |D Harald |u Central Institute of Blood Transfusion and Immunology, University Hospital Innsbruck, A-6020 Innsbruck, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fuchs |D Dietmar |u Institute of Medical Chemistry and Biochemistry, Innsbruck Medical University, A-6020 Innsbruck, Austria and Ludwig Boltzmann Institute of AIDS-Research, A-6020 Innsbruck, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biological Chemistry |d Walter de Gruyter |g 385/12(2004-12-01), 1197-1202 |x 1431-6730 |q 385:12<1197 |1 2004 |2 385 |o bchm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||