caa a22 4500 378898019 CHVBK 20180305123511.0 cr unu---uuuuu 161128e20040216xx s 000 0 eng 10.1515/CCLM.2004.002 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.002 Panteghini Mauro Current concepts in standardization of cardiac marker immunoassays [Elektronische Daten] [Mauro Panteghini] Cardiac markers are measured by a number of different immunoassays using specific antibodies directed to the respective antigens. Lacking assay standardization, different results from different assays measuring the same marker may be obtained and this problem may cloud interpretations of reported data. Presently, there are no reference procedures for cardiac markers; certified reference materials should still be established and, at least for cardiac troponins, the analyte in the patients' blood is significantly different from newly synthesized protein. It is therefore clear that the problems of cardiac marker standardization will not be quickly solved. A number of projects are, however, underway under the auspices of the IFCC and other organizations. The aim of this opinion is to reflect on some concepts related to the implementation of a metrologically correct measurement system, giving practical examples on how these concepts can be applied to immunoassays measuring cardiac markers. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/1(2004-02-16), 3-8 1434-6621 42:1<3 2004 42 cclm https://doi.org/10.1515/CCLM.2004.002 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.002 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Panteghini Mauro NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/1(2004-02-16), 3-8 1434-6621 42:1<3 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter