caa a22 4500 378898116 CHVBK 20180305123511.0 cr unu---uuuuu 161128e20041201xx s 000 0 eng 10.1515/CCLM.2004.259 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.259 Declines in serum free and bound choline concentrations in humans after three different types of major surgery [Elektronische Daten] [Yesim Ozarda Ilcol, Gurkan Uncu, Suna Goren, Erkan Sayan, Ismail H. Ulus] We examined the changes in circulating choline status in humans in response to major surgery by measuring serum free and phospholipid-bound choline concentrations before, during and 1-72h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery. Preoperatively, the mean serum free and phospholipid-bound choline concentrations in patients scheduled for abdominal hysterectomy (n=26), off-pump coronary artery grafting surgery (n=34) or brain tumor surgery (n=24) were 12.3±0.5, 12.1±0.4 and 11.4±0.4μmol/l, and 2495±75, 2590±115 and 2625±80μmol/l, respectively. Serum free choline and phospholipid-bound choline concentrations decreased from these baseline values to 8.8±0.7 (p<0.001), 8.8±0.5 (p<0.001) and 8.2±0.4μmol/l (p<0.001), and 2050±108 (p<0.001), 2166±59 (p<0.001) and 1884±104μmol/l (p<0.001) at 1h after hysterectomy, off-pump bypass graft surgery or brain tumor surgery, respectively. They remained at these low levels for 24h and then gradually increased towards the preoperative values at 48-72h postoperatively. Serum cortisol increased postoperatively in all surgical patients for 24h and its levels were inversely correlated with serum free and bound choline concentrations. These results show that circulating free and bound choline concentrations decrease for 72h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery in humans. ©2004 by Walter de Gruyter Berlin New York Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence bound choline nationallicence brain surgery nationallicence cortisol nationallicence free choline nationallicence hysterectomy nationallicence surgical stress nationallicence Ilcol Yesim Ozarda Department of Biochemistry and Clinical Biochemistry, Uludag University Medical School, Bursa, Turkey aut Uncu Gurkan Department of Obstetrics and Gynecology, Uludag University Medical School, Bursa, Turkey aut Goren Suna Department of Anesthesiology and Reanimation, Uludag University Medical School, Bursa, Turkey aut Sayan Erkan Department of Anesthesiology and Reanimation, Uludag University Medical School, Bursa, Turkey aut Ulus Ismail H. Department of Pharmacology and Clinical Pharmacology, Uludag University Medical School, Bursa, Turkey aut Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1390-1395 1434-6621 42:12<1390 2004 42 cclm https://doi.org/10.1515/CCLM.2004.259 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.259 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ilcol Yesim Ozarda Department of Biochemistry and Clinical Biochemistry, Uludag University Medical School, Bursa, Turkey aut NATIONALLICENCE 700 1- Uncu Gurkan Department of Obstetrics and Gynecology, Uludag University Medical School, Bursa, Turkey aut NATIONALLICENCE 700 1- Goren Suna Department of Anesthesiology and Reanimation, Uludag University Medical School, Bursa, Turkey aut NATIONALLICENCE 700 1- Sayan Erkan Department of Anesthesiology and Reanimation, Uludag University Medical School, Bursa, Turkey aut NATIONALLICENCE 700 1- Ulus Ismail H. Department of Pharmacology and Clinical Pharmacology, Uludag University Medical School, Bursa, Turkey aut NATIONALLICENCE 773 0- Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1390-1395 1434-6621 42:12<1390 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter