Hyperhomocysteinaemia is associated with uveitis but not with deep venous thrombosis in Behçet's disease
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| 024 | 7 | 0 | |a 10.1515/CCLM.2004.263 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.263 | ||
| 245 | 0 | 0 | |a Hyperhomocysteinaemia is associated with uveitis but not with deep venous thrombosis in Behçet's disease |h [Elektronische Daten] |c [Moncef Feki, Habib Houman, Mehdi Ghannouchi, Monia Smiti-Khanfir, Kamel Hamzaoui, Leila El Matri, Abderraouf Mebazaa, Neziha Kaabachi] |
| 520 | 3 | |a Plasma homocysteine was assessed in Behçet's disease (BD) patients in order to determine the prevalence of hyperhomocysteinaemia in BD and to test its association with clinical manifestations of the disease. The study included 59 patients with BD and 118 age- and sex-matched healthy subjects. Plasma homocysteine, vitamin B12 and folate were assessed by automated immunoassay methods. Hyperhomo-cysteinaemia was defined as plasma homocysteine >15μmol/l. Plasma homocysteine concentrations and the prevalence of hyperhomocysteinaemia were significantly higher in BD patients than in controls [median (5th-95th percentile), 11.3 (6.6-28.1) vs. 10.6 (6.6-17.1)μmol/l, and 25.4% vs. 9.3%, respectively]. In BD patients, hyperhomocysteinaemia was related to male gender, disease severity and uveitis [odds ratio (OR), 5.32; 95% confidence interval (CI), 1.43-21.61; p=0.008], but not to age, smoking, disease activity, deep venous thrombosis, arthritis or neurological involvement. The association between uveitis and hyperhomocysteinaemia persisted (multi-adjusted OR, 7.46; 95% CI, 1.03-54.3; p=0.05) after adjusting for gender, age, disease activity and duration, smoking, deep venous thrombosis, and serum concentrations of creatinine, vitamin B12 and folate. Plasma homocysteine should be measured in patients with BD, and the effect of B-vitamin supplementation should be tested in those with hyperhomo-cysteinaemia. | |
| 540 | |a ©2004 by Walter de Gruyter Berlin New York | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 690 | 7 | |a Behçet's disease |2 nationallicence | |
| 690 | 7 | |a deep venous thrombosis |2 nationallicence | |
| 690 | 7 | |a endothelial dysfunction |2 nationallicence | |
| 690 | 7 | |a homocysteine |2 nationallicence | |
| 690 | 7 | |a oxidant stress |2 nationallicence | |
| 690 | 7 | |a retinal vasculitis |2 nationallicence | |
| 690 | 7 | |a uveitis |2 nationallicence | |
| 700 | 1 | |a Feki |D Moncef |u LAB-SM-01 Research Laboratory & Department of Biochemistry, Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia |4 aut | |
| 700 | 1 | |a Houman |D Habib |u Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia |4 aut | |
| 700 | 1 | |a Ghannouchi |D Mehdi |u Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia |4 aut | |
| 700 | 1 | |a Smiti-Khanfir |D Monia |u Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia |4 aut | |
| 700 | 1 | |a Hamzaoui |D Kamel |u Department of Histology, Faculty of Medicine, Tunis, Tunisia |4 aut | |
| 700 | 1 | |a Matri |D Leila El |u Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia and Institute of Ophthalmology, Tunis, Tunisia |4 aut | |
| 700 | 1 | |a Mebazaa |D Abderraouf |u LAB-SM-01 Research Laboratory & Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia |4 aut | |
| 700 | 1 | |a Kaabachi |D Neziha |u LAB-SM-01 Research Laboratory & Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia |4 aut | |
| 773 | 0 | |t Clinical Chemical Laboratory Medicine |d Walter de Gruyter |g 42/12(2004-12-01), 1417-1423 |x 1434-6621 |q 42:12<1417 |1 2004 |2 42 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2004.263 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2004.263 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Feki |D Moncef |u LAB-SM-01 Research Laboratory & Department of Biochemistry, Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Houman |D Habib |u Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ghannouchi |D Mehdi |u Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Smiti-Khanfir |D Monia |u Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hamzaoui |D Kamel |u Department of Histology, Faculty of Medicine, Tunis, Tunisia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Matri |D Leila El |u Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia and Institute of Ophthalmology, Tunis, Tunisia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mebazaa |D Abderraouf |u LAB-SM-01 Research Laboratory & Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kaabachi |D Neziha |u LAB-SM-01 Research Laboratory & Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemical Laboratory Medicine |d Walter de Gruyter |g 42/12(2004-12-01), 1417-1423 |x 1434-6621 |q 42:12<1417 |1 2004 |2 42 |o cclm | ||
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