caa a22 4500 378898124 CHVBK 20180305123511.0 cr unu---uuuuu 161128e20041201xx s 000 0 eng 10.1515/CCLM.2004.263 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.263 Hyperhomocysteinaemia is associated with uveitis but not with deep venous thrombosis in Behçet's disease [Elektronische Daten] [Moncef Feki, Habib Houman, Mehdi Ghannouchi, Monia Smiti-Khanfir, Kamel Hamzaoui, Leila El Matri, Abderraouf Mebazaa, Neziha Kaabachi] Plasma homocysteine was assessed in Behçet's disease (BD) patients in order to determine the prevalence of hyperhomocysteinaemia in BD and to test its association with clinical manifestations of the disease. The study included 59 patients with BD and 118 age- and sex-matched healthy subjects. Plasma homocysteine, vitamin B12 and folate were assessed by automated immunoassay methods. Hyperhomo-cysteinaemia was defined as plasma homocysteine >15μmol/l. Plasma homocysteine concentrations and the prevalence of hyperhomocysteinaemia were significantly higher in BD patients than in controls [median (5th-95th percentile), 11.3 (6.6-28.1) vs. 10.6 (6.6-17.1)μmol/l, and 25.4% vs. 9.3%, respectively]. In BD patients, hyperhomocysteinaemia was related to male gender, disease severity and uveitis [odds ratio (OR), 5.32; 95% confidence interval (CI), 1.43-21.61; p=0.008], but not to age, smoking, disease activity, deep venous thrombosis, arthritis or neurological involvement. The association between uveitis and hyperhomocysteinaemia persisted (multi-adjusted OR, 7.46; 95% CI, 1.03-54.3; p=0.05) after adjusting for gender, age, disease activity and duration, smoking, deep venous thrombosis, and serum concentrations of creatinine, vitamin B12 and folate. Plasma homocysteine should be measured in patients with BD, and the effect of B-vitamin supplementation should be tested in those with hyperhomo-cysteinaemia. ©2004 by Walter de Gruyter Berlin New York Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence Behçet's disease nationallicence deep venous thrombosis nationallicence endothelial dysfunction nationallicence homocysteine nationallicence oxidant stress nationallicence retinal vasculitis nationallicence uveitis nationallicence Feki Moncef LAB-SM-01 Research Laboratory & Department of Biochemistry, Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia aut Houman Habib Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia aut Ghannouchi Mehdi Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia aut Smiti-Khanfir Monia Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia aut Hamzaoui Kamel Department of Histology, Faculty of Medicine, Tunis, Tunisia aut Matri Leila El Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia and Institute of Ophthalmology, Tunis, Tunisia aut Mebazaa Abderraouf LAB-SM-01 Research Laboratory & Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia aut Kaabachi Neziha LAB-SM-01 Research Laboratory & Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia aut Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1417-1423 1434-6621 42:12<1417 2004 42 cclm https://doi.org/10.1515/CCLM.2004.263 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.263 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Feki Moncef LAB-SM-01 Research Laboratory & Department of Biochemistry, Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia aut NATIONALLICENCE 700 1- Houman Habib Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia aut NATIONALLICENCE 700 1- Ghannouchi Mehdi Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia aut NATIONALLICENCE 700 1- Smiti-Khanfir Monia Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia aut NATIONALLICENCE 700 1- Hamzaoui Kamel Department of Histology, Faculty of Medicine, Tunis, Tunisia aut NATIONALLICENCE 700 1- Matri Leila El Behçet's Disease Research Unit & Department of Internal Medicine, Rabta University Hospital, Tunis, Tunisia and Institute of Ophthalmology, Tunis, Tunisia aut NATIONALLICENCE 700 1- Mebazaa Abderraouf LAB-SM-01 Research Laboratory & Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia aut NATIONALLICENCE 700 1- Kaabachi Neziha LAB-SM-01 Research Laboratory & Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia aut NATIONALLICENCE 773 0- Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1417-1423 1434-6621 42:12<1417 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter