caa a22 4500 378898140 CHVBK 20180305123511.0 cr unu---uuuuu 161128e20041201xx s 000 0 eng 10.1515/CCLM.2004.264 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.264 Production of gender-specific morning salivary cortisol reference intervals using internationally accepted procedures [Elektronische Daten] [Rajan S. Patel, Steve R. Shaw, Halena MacIntyre, Gerald W. McGarry, A. Michael Wallace] Background: Salivary cortisol concentrations correlate well with biologically active unbound free plasma cortisol concentrations. Despite its practical and analytical advantages, salivary cortisol measurement has been used mainly as a research tool rather than for the routine evaluation of adrenal function. This may be partly explained by the lack of robust reference data in the literature. Methods: Using the recommended procedures for the production of reference intervals published by the International Federation of Clinical Chemistry, we aimed to produce morning salivary cortisol reference intervals for males and females. Salivary cortisol was measured in 496 specimens collected from 248 reference individuals (128 males, median age 41years, range 16-86; and 120 females, median age 44years, range 16-98) attending an otorhinolaryngology clinic. Reference individuals mailed saliva specimens sampled on two consecutive mornings to our laboratory, where cortisol concentrations were measured. Results: Statistical analysis showed no significant correlation with age or body mass index. The following 95% gender-partitioned reference intervals were produced: males 10.9-40.3nmol/l; and females 9.3-40.3nmol/l. Conclusion: Knowledge of these salivary cortisol reference intervals helps us monitor the adrenal function of outpatients using topical intranasal glucocorticoids for rhinosinusitis. ©2004 by Walter de Gruyter Berlin New York Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence adrenal suppression nationallicence cortisol nationallicence reference interval nationallicence saliva nationallicence steroids nationallicence Patel Rajan S. Department of Otolaryngology, North Glasgow Hospitals University NHS Trust, Alexandra Parade, Glasgow, UK aut Shaw Steve R. School of Mathematics and Statistics, University of Plymouth, Plymouth, UK aut MacIntyre Halena Department of Clinical Biochemistry, North Glasgow Hospitals University NHS Trust, Alexandra Parade, Glasgow, UK aut McGarry Gerald W. Department of Otolaryngology, North Glasgow Hospitals University NHS Trust, Alexandra Parade, Glasgow, UK aut Michael Wallace A. Department of Clinical Biochemistry, North Glasgow Hospitals University NHS Trust, Alexandra Parade, Glasgow, UK aut Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1424-1429 1434-6621 42:12<1424 2004 42 cclm https://doi.org/10.1515/CCLM.2004.264 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.264 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Patel Rajan S. Department of Otolaryngology, North Glasgow Hospitals University NHS Trust, Alexandra Parade, Glasgow, UK aut NATIONALLICENCE 700 1- Shaw Steve R. School of Mathematics and Statistics, University of Plymouth, Plymouth, UK aut NATIONALLICENCE 700 1- MacIntyre Halena Department of Clinical Biochemistry, North Glasgow Hospitals University NHS Trust, Alexandra Parade, Glasgow, UK aut NATIONALLICENCE 700 1- McGarry Gerald W. Department of Otolaryngology, North Glasgow Hospitals University NHS Trust, Alexandra Parade, Glasgow, UK aut NATIONALLICENCE 700 1- Michael Wallace A. Department of Clinical Biochemistry, North Glasgow Hospitals University NHS Trust, Alexandra Parade, Glasgow, UK aut NATIONALLICENCE 773 0- Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1424-1429 1434-6621 42:12<1424 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter