caa a22 4500 378898159 CHVBK 20180305123511.0 cr unu---uuuuu 161128e20041201xx s 000 0 eng 10.1515/CCLM.2004.266 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.266 External Quality Assessment for biochemical markers of myocardial damage: an Italian experience [Elektronische Daten] [Martina Zaninotto, Laura Sciacovelli, Franca Pagani, Mauro Panteghini, Mario Plebani] In 1999 the Centre of Biomedical Research (CRB) in co-operation with the Italian interdisciplinary and intersociety Working Group on Markers of Myocardial Damage proposed a national external quality assurance scheme that was granted in accordance with the UK Clinical Pathology Accreditation Standards in 2001. The scheme, which stresses the importance of educational aspects in quality assurance, was scientifically designed to ensure that it would provide an objective assessment of participants' performance and promote quality improvements to meet the needs of participants. The present paper reports on the data collected in EQA cycles conducted to evaluate improvements in the performance of participants and in related methods. The findings obtained demonstrate that during the 4-year experience the scheme provided opportunities to improve the performance of laboratories and promoted an efficient, more satisfactory approach to analytical aspects. The number of unacceptable performances decreased from 11.6% to 5.6% for troponin I, from 19.5% to 9.0% for myoglobin and from 13.2% to 4.3% for creatine kinase myocardial isoenzyme (CK-MB). During cycles in 2001 and 2002, inter-variability (coefficient of variation, CV%) data for all markers appeared satisfactory and showed a significant improvement (lower than 10%), in particular for procedures automated on Dade Behring Dimension and Beckman Access systems. However, reference values/decisional limits declared by laboratories and those suggested by the manufacturers are not comparable, even within the same diagnostic system. The findings demonstrate that participation in EQA schemes provided an opportunity for participating laboratories to continuously improve the quality of their services. ©2004 by Walter de Gruyter Berlin New York Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence cardiac markers nationallicence decisional levels nationallicence External Quality Assessment nationallicence laboratory performance nationallicence method performance nationallicence Zaninotto Martina Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy aut Sciacovelli Laura Centre of Biomedical Research, Castelfranco Veneto, Treviso, Italy aut Pagani Franca First Laboratory of Clinical Chemistry, Azienda Ospedaliera "Spedali Civili”, Brescia, Italy aut Panteghini Mauro First Laboratory of Clinical Chemistry, Azienda Ospedaliera "Spedali Civili”, Brescia, Italy aut Plebani Mario Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy and Centre of Biomedical Research, Castelfranco Veneto, Treviso, Italy aut Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1434-1441 1434-6621 42:12<1434 2004 42 cclm https://doi.org/10.1515/CCLM.2004.266 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.266 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zaninotto Martina Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy aut NATIONALLICENCE 700 1- Sciacovelli Laura Centre of Biomedical Research, Castelfranco Veneto, Treviso, Italy aut NATIONALLICENCE 700 1- Pagani Franca First Laboratory of Clinical Chemistry, Azienda Ospedaliera "Spedali Civili”, Brescia, Italy aut NATIONALLICENCE 700 1- Panteghini Mauro First Laboratory of Clinical Chemistry, Azienda Ospedaliera "Spedali Civili”, Brescia, Italy aut NATIONALLICENCE 700 1- Plebani Mario Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy and Centre of Biomedical Research, Castelfranco Veneto, Treviso, Italy aut NATIONALLICENCE 773 0- Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1434-1441 1434-6621 42:12<1434 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter