caa a22 4500 378898205 CHVBK 20180305123511.0 cr unu---uuuuu 161128e20041201xx s 000 0 eng 10.1515/CCLM.2004.262 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.262 HDL and clinical and biochemical correlates in Italian non-smoker women [Elektronische Daten] [Federico Bigazzi, Beatrice Dal Pino, Francesco Forastiere, Riccardo Pistelli, Giuseppe Rossi, Marzia Simoni, Sandra Baldacci, Giovanni Viegi, Alberto Bionda, Tiziana Sampietro] High-density lipoprotein (HDL)-cholesterol levels, inversely related to the risk of myocardial infarction, are determined by genetic and environmental factors. The aim of this study was to evaluate the prevalence of low and high HDL plasma levels and the influence of environmental factors and lipid profile in an Italian non-smoker female population. HDL, apolipoprotein A-I, apolipoproteins, lipids and estrogen plasma levels were measured in a population of 1471 women with a mean age of 45±14years. HDL values ≤35mg/dl were noted in 11.2% of the subjects, showing 2.4% coronary heart disease (CHD) prevalence. The 90th percentile was characterized by HDL levels ≥66mg/dl and the absence of coronary atherosclerosis. Total cholesterol, apolipoprotein B and triglycerides (r=−0.31, p<0.0001) were the main determinants of HDL levels; apolipoprotein E, estrogen use, body mass index (BMI), alcohol consumption and age showed a weaker correlation. Apolipoprotein A-I concentration was influenced more notably by estrogen use, total cholesterol and apolipoprotein E; levels of triglycerides, apolipoprotein B, BMI, age and alcohol consumption are less important. The parameters considered here, taken together, explain HDL and apolipoprotein A-I variability of approximately 31% and 24%, respectively. A surprisingly high prevalence of very low (≤35mg/dl) and high (≥66mg/dl) HDL levels in Italian women further confirms the importance of studies on the HDL distribution in different population groups. ©2004 by Walter de Gruyter Berlin New York Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence apolipoprotein A-I nationallicence coronary heart disease nationallicence estrogens nationallicence high-density lipoprotein nationallicence hypoalphalipoproteinemia nationallicence Bigazzi Federico CNR Institute of Clinical Physiology, Pisa, Italy and Department of Internal Medicine, University of Pisa, Pisa, Italy aut Pino Beatrice Dal CNR Institute of Clinical Physiology, Pisa, Italy aut Forastiere Francesco Department of Epidemiology, Health Authority, Rome, Italy aut Pistelli Riccardo Department of Respiratory Physiology, Catholic University, Rome, Italy aut Rossi Giuseppe CNR Institute of Clinical Physiology, Pisa, Italy aut Simoni Marzia CNR Institute of Clinical Physiology, Pisa, Italy aut Baldacci Sandra CNR Institute of Clinical Physiology, Pisa, Italy aut Viegi Giovanni CNR Institute of Clinical Physiology, Pisa, Italy aut Bionda Alberto Department of Internal Medicine, University of Pisa, Pisa, Italy aut Sampietro Tiziana CNR Institute of Clinical Physiology, Pisa, Italy aut Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1408-1416 1434-6621 42:12<1408 2004 42 cclm https://doi.org/10.1515/CCLM.2004.262 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.262 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bigazzi Federico CNR Institute of Clinical Physiology, Pisa, Italy and Department of Internal Medicine, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Pino Beatrice Dal CNR Institute of Clinical Physiology, Pisa, Italy aut NATIONALLICENCE 700 1- Forastiere Francesco Department of Epidemiology, Health Authority, Rome, Italy aut NATIONALLICENCE 700 1- Pistelli Riccardo Department of Respiratory Physiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Rossi Giuseppe CNR Institute of Clinical Physiology, Pisa, Italy aut NATIONALLICENCE 700 1- Simoni Marzia CNR Institute of Clinical Physiology, Pisa, Italy aut NATIONALLICENCE 700 1- Baldacci Sandra CNR Institute of Clinical Physiology, Pisa, Italy aut NATIONALLICENCE 700 1- Viegi Giovanni CNR Institute of Clinical Physiology, Pisa, Italy aut NATIONALLICENCE 700 1- Bionda Alberto Department of Internal Medicine, University of Pisa, Pisa, Italy aut NATIONALLICENCE 700 1- Sampietro Tiziana CNR Institute of Clinical Physiology, Pisa, Italy aut NATIONALLICENCE 773 0- Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1408-1416 1434-6621 42:12<1408 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter