caa a22 4500 37889823X CHVBK 20180305123511.0 cr unu---uuuuu 161128e20041201xx s 000 0 eng 10.1515/CCLM.2004.253 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.253 Hematopoietic cytokines as tumor markers [Elektronische Daten] [Barbara Mroczko, Maciej Szmitkowski] Stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage-colony stimulating factor (GM-CSF), granulocyte-colony stimulating factor (G-CSF) and macrophage-colony stimulating factor (M-CSF) are members of a group of glycoproteins called hematopoietic cytokines (HCs). These cytokines regulate the growth and differentiation of hematopoietic progenitor cells and functionally activate mature neutrophils or macrophages. The effect of HCs is not limited to bone marrow cells. Some studies have shown that HCs can also stimulate the proliferation of non-hematopoietic cells. The receptors for HCs have been detected in cancer cell lines, and stimulation of HCs receptors induced proliferation of tumor cells. Moreover, some investigations have shown HC mRNA expression in these cell lines and recent studies have demonstrated that HCs can stimulate tumor progression. Several cells of malignant tumors have been observed to secrete large amounts of HCs and increased concentrations of HCs have been found in the sera of cancer patients. There are a number of situations in which the measurement of HCs may provide clinically useful information, particularly regarding prognosis and response to treatment. In this paper we discuss the results of studies that have examined the potential use of HCs as tumor markers. ©2004 by Walter de Gruyter Berlin New York Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence hematopoietic cytokines nationallicence tumor markers nationallicence Mroczko Barbara Department of Biochemical Diagnostics, Medical Academy, Bialystok, Poland aut Szmitkowski Maciej Department of Biochemical Diagnostics, Medical Academy, Bialystok, Poland aut Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1347-1354 1434-6621 42:12<1347 2004 42 cclm https://doi.org/10.1515/CCLM.2004.253 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.253 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mroczko Barbara Department of Biochemical Diagnostics, Medical Academy, Bialystok, Poland aut NATIONALLICENCE 700 1- Szmitkowski Maciej Department of Biochemical Diagnostics, Medical Academy, Bialystok, Poland aut NATIONALLICENCE 773 0- Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1347-1354 1434-6621 42:12<1347 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter