Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke
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| 024 | 7 | 0 | |a 10.1515/CCLM.2004.256 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.256 | ||
| 245 | 0 | 0 | |a Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke |h [Elektronische Daten] |c [Larry Baum, Ka Sing Wong, Ho Keung Ng, Brian Tomlinson, Timothy Hudson Rainer, Daniel Kam Yin Chan, G. Neil Thomas, Xiangyan Chen, Peter Poon, Wing Sze Cheung, Kam Sang Woo] |
| 520 | 3 | |a The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 677C→T polymorphism causes an A222V amino acid change which affects MTHFR enzyme activity and can increase homocysteine, a vascular disease risk factor. This polymorphism was examined for association with stroke. In a case-control study of 241 ischemic stroke patients and 304 controls in Hong Kong, the V allele increased in stroke [28% vs. 20%, odds ratio (OR) 1.5, p=0.003]. A lack of significance for the increase in the VV genotype (7.5% vs. 4.6%, OR 1.7, p=0.16) may be due to its rarity in this region. V-allele carriers had more severe strokes (according to the NIH stroke scale). The association of the V allele with stroke occurred mostly in women or older subjects and was due to decreasing V allele frequency with age, as seen in other studies. This V frequency decline with age might be due to a loss of V-carrying controls from a higher risk of cancer, vascular disease, bone fracture, and kidney failure when folate is sparse. Examination of previous studies revealed that the association of VV genotype with stroke appeared stronger in Japan than elsewhere, possibly due to dietary differences. Perhaps folate supplementation for stroke prevention would particularly benefit VV individuals in such high-risk regions. | |
| 540 | |a ©2004 by Walter de Gruyter Berlin New York | ||
| 690 | 7 | |a Medical equipment & techniques |2 nationallicence | |
| 690 | 7 | |a Medical diagnosis |2 nationallicence | |
| 690 | 7 | |a Diseases & disorders |2 nationallicence | |
| 690 | 7 | |a elderly |2 nationallicence | |
| 690 | 7 | |a folate |2 nationallicence | |
| 690 | 7 | |a methylenetetrahydrofolate reductase (MTHFR) |2 nationallicence | |
| 690 | 7 | |a mutation |2 nationallicence | |
| 690 | 7 | |a polymorphism |2 nationallicence | |
| 690 | 7 | |a stroke |2 nationallicence | |
| 700 | 1 | |a Baum |D Larry |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | |
| 700 | 1 | |a Wong |D Ka Sing |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | |
| 700 | 1 | |a Ng |D Ho Keung |u Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | |
| 700 | 1 | |a Tomlinson |D Brian |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | |
| 700 | 1 | |a Rainer |D Timothy Hudson |u Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | |
| 700 | 1 | |a Chan |D Daniel Kam Yin |u Department of Age Care and Rehabilitation, Bankstown Health Service, (University of New South Wales), New South Wales, Australia |4 aut | |
| 700 | 1 | |a Thomas |D G. Neil |u Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, PR China |4 aut | |
| 700 | 1 | |a Chen |D Xiangyan |u Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | |
| 700 | 1 | |a Poon |D Peter |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | |
| 700 | 1 | |a Cheung |D Wing Sze |u Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | |
| 700 | 1 | |a Woo |D Kam Sang |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | |
| 773 | 0 | |t Clinical Chemical Laboratory Medicine |d Walter de Gruyter |g 42/12(2004-12-01), 1370-1376 |x 1434-6621 |q 42:12<1370 |1 2004 |2 42 |o cclm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/CCLM.2004.256 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/CCLM.2004.256 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Baum |D Larry |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wong |D Ka Sing |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ng |D Ho Keung |u Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tomlinson |D Brian |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rainer |D Timothy Hudson |u Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chan |D Daniel Kam Yin |u Department of Age Care and Rehabilitation, Bankstown Health Service, (University of New South Wales), New South Wales, Australia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Thomas |D G. Neil |u Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chen |D Xiangyan |u Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Poon |D Peter |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cheung |D Wing Sze |u Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Woo |D Kam Sang |u Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Clinical Chemical Laboratory Medicine |d Walter de Gruyter |g 42/12(2004-12-01), 1370-1376 |x 1434-6621 |q 42:12<1370 |1 2004 |2 42 |o cclm | ||
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