caa a22 4500 378898272 CHVBK 20180305123511.0 cr unu---uuuuu 161128e20041201xx s 000 0 eng 10.1515/CCLM.2004.256 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.256 Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke [Elektronische Daten] [Larry Baum, Ka Sing Wong, Ho Keung Ng, Brian Tomlinson, Timothy Hudson Rainer, Daniel Kam Yin Chan, G. Neil Thomas, Xiangyan Chen, Peter Poon, Wing Sze Cheung, Kam Sang Woo] The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 677C→T polymorphism causes an A222V amino acid change which affects MTHFR enzyme activity and can increase homocysteine, a vascular disease risk factor. This polymorphism was examined for association with stroke. In a case-control study of 241 ischemic stroke patients and 304 controls in Hong Kong, the V allele increased in stroke [28% vs. 20%, odds ratio (OR) 1.5, p=0.003]. A lack of significance for the increase in the VV genotype (7.5% vs. 4.6%, OR 1.7, p=0.16) may be due to its rarity in this region. V-allele carriers had more severe strokes (according to the NIH stroke scale). The association of the V allele with stroke occurred mostly in women or older subjects and was due to decreasing V allele frequency with age, as seen in other studies. This V frequency decline with age might be due to a loss of V-carrying controls from a higher risk of cancer, vascular disease, bone fracture, and kidney failure when folate is sparse. Examination of previous studies revealed that the association of VV genotype with stroke appeared stronger in Japan than elsewhere, possibly due to dietary differences. Perhaps folate supplementation for stroke prevention would particularly benefit VV individuals in such high-risk regions. ©2004 by Walter de Gruyter Berlin New York Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence elderly nationallicence folate nationallicence methylenetetrahydrofolate reductase (MTHFR) nationallicence mutation nationallicence polymorphism nationallicence stroke nationallicence Baum Larry Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut Wong Ka Sing Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut Ng Ho Keung Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut Tomlinson Brian Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut Rainer Timothy Hudson Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut Chan Daniel Kam Yin Department of Age Care and Rehabilitation, Bankstown Health Service, (University of New South Wales), New South Wales, Australia aut Thomas G. Neil Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, PR China aut Chen Xiangyan Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut Poon Peter Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut Cheung Wing Sze Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut Woo Kam Sang Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1370-1376 1434-6621 42:12<1370 2004 42 cclm https://doi.org/10.1515/CCLM.2004.256 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.256 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baum Larry Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut NATIONALLICENCE 700 1- Wong Ka Sing Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut NATIONALLICENCE 700 1- Ng Ho Keung Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut NATIONALLICENCE 700 1- Tomlinson Brian Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut NATIONALLICENCE 700 1- Rainer Timothy Hudson Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut NATIONALLICENCE 700 1- Chan Daniel Kam Yin Department of Age Care and Rehabilitation, Bankstown Health Service, (University of New South Wales), New South Wales, Australia aut NATIONALLICENCE 700 1- Thomas G. Neil Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, PR China aut NATIONALLICENCE 700 1- Chen Xiangyan Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut NATIONALLICENCE 700 1- Poon Peter Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut NATIONALLICENCE 700 1- Cheung Wing Sze Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut NATIONALLICENCE 700 1- Woo Kam Sang Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China aut NATIONALLICENCE 773 0- Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1370-1376 1434-6621 42:12<1370 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter