caa a22 4500 378898310 CHVBK 20180305123511.0 cr unu---uuuuu 161128e20041201xx s 000 0 eng 10.1515/CCLM.2004.265 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.265 Concentrations of N-terminal pro-brain natriuretic peptide and troponin T in plasma of 75-year-old apparently healthy persons [Elektronische Daten] [Klaus Roland Huber, Nazanin Mostafaie, Kurt Bauer, Brigitte Worofka, Eva Kittl, Jörg Hofmann, Milos Hejtman, Karoly Redei, Susanne Jungwirth, Peter Fischer, Karl-Heinz Tragl] Clinical chemical reference values for older persons are sparse and mostly intermixed with those for younger persons. We had a unique opportunity to obtain blood samples from volunteers who were 75years old and living in two districts of Vienna, Austria. Consequently, we utilized stored plasma samples to obtain reference intervals for 120 apparently healthy 75-year-old participants for pro-brain natriuretic peptide (proBNP), as well as for troponin T. The N-terminal (NT)-proBNP protein assay is currently used as a diagnostic and prognostic aid in patients with heart failure and as a prognostic marker in acute coronary syndromes. Specifically, the concentration of NT-proBNP in serum or plasma aids in the prognosis of ventricular systolic dysfunction and helps to differentiate between cardiac and non-cardiac causes. The median NT-proBNP plasma value for men and women in our cohort was calculated as 98pg/ml, comparing favorably with reported values, in that a NT-proBNP concentration less than 100pg/ml excludes acutely decompensated heart failure. Our calculated 97.5 percentile was slightly higher (359 pg/ml) than the 97.5 percentile in a group of 50-65-year-old persons (198 and 222pg/ml for men and women, respectively) revealing the influence of age on this parameter. Because of its high tissue-specificity, cardiac troponin T is a cardiospecific, highly sensitive marker for myocardial damage. However, the troponin T concentrations in the plasma specimens from this cohort were all below the detection limit of 0.01ng/ml, preventing any further data handling. ©2004 by Walter de Gruyter Berlin New York Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence heart failure nationallicence N-terminal pro-brain natriuretic peptide (NT-proBNP) nationallicence prognostic marker nationallicence reference interval nationallicence troponin T nationallicence Huber Klaus Roland Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut Mostafaie Nazanin Ludwig Boltzmann-Institut für Altersforschung, Donauspital, Vienna, Austria aut Bauer Kurt Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut Worofka Brigitte Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut Kittl Eva Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut Hofmann Jörg Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut Hejtman Milos Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut Redei Karoly Roche Diagnostics Inc, Vienna, Austria aut Jungwirth Susanne Ludwig Boltzmann-Institut für Altersforschung, Donauspital, Vienna, Austria aut Fischer Peter Ludwig Boltzmann-Institut für Altersforschung, Donauspital, Vienna, Austria aut Tragl Karl-Heinz Ludwig Boltzmann-Institut für Altersforschung, Donauspital, Vienna, Austria aut Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1430-1433 1434-6621 42:12<1430 2004 42 cclm https://doi.org/10.1515/CCLM.2004.265 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.265 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huber Klaus Roland Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut NATIONALLICENCE 700 1- Mostafaie Nazanin Ludwig Boltzmann-Institut für Altersforschung, Donauspital, Vienna, Austria aut NATIONALLICENCE 700 1- Bauer Kurt Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut NATIONALLICENCE 700 1- Worofka Brigitte Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut NATIONALLICENCE 700 1- Kittl Eva Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut NATIONALLICENCE 700 1- Hofmann Jörg Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut NATIONALLICENCE 700 1- Hejtman Milos Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik, Donauspital, Vienna, Austria aut NATIONALLICENCE 700 1- Redei Karoly Roche Diagnostics Inc, Vienna, Austria aut NATIONALLICENCE 700 1- Jungwirth Susanne Ludwig Boltzmann-Institut für Altersforschung, Donauspital, Vienna, Austria aut NATIONALLICENCE 700 1- Fischer Peter Ludwig Boltzmann-Institut für Altersforschung, Donauspital, Vienna, Austria aut NATIONALLICENCE 700 1- Tragl Karl-Heinz Ludwig Boltzmann-Institut für Altersforschung, Donauspital, Vienna, Austria aut NATIONALLICENCE 773 0- Clinical Chemical Laboratory Medicine Walter de Gruyter 42/12(2004-12-01), 1430-1433 1434-6621 42:12<1430 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter