caa a22 4500 378899368 CHVBK 20180305123514.0 cr unu---uuuuu 161128e20041001xx s 000 0 mul 10.1515/LabMed.2004.054 doi (NATIONALLICENCE)gruyter-10.1515/LabMed.2004.054 Diagnostic work-up of iron deficiency [Elektronische Daten] Diagnostisches Vorgehen bei Eisenmangel / [Georgia Metzgeroth, Jan Hastka] Abstract Iron deficiency (ID) is defined as a diminished total body iron content. Three degrees of severity have been defined: storage iron depletion (stage I), iron-deficient erythropoiesis (stage II), and iron deficiency anemia (stage III). When assessing the patient's iron status, it is important to bear in mind that each of the various iron tests indicate something different in terms of ID. As they detect different stages of ID, the parameters efficiently complement each other to characterize the iron status in the individual patient. Of particular clinical interest are newer iron tests of the iron-deficient erythropoiesis: zinc protoporphyrin (ZPP), soluble transferrin receptor (sTfR), hypochrome erythrocytes (Hypo) and reticulocyte hemoglobin (CHr). Supervising the final step of the heme production, ZPP can be used as a reliable and inexpensive screening test of the whole iron metabolism. sTfR measurement is a useful tool to distinguish between real iron deficiency and functional iron deficiency in anemia of chronic disorders. Hypo and CHr seem to be the best parameters to diagnose ID in hemodialysis patients treated with recombinant human erythropoietin. © Walter de Gruyter Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence ferritin nationallicence hypochrome erythrocytes nationallicence iron deficiency nationallicence reticulocyte hemoglobin nationallicence soluble transferrin receptor nationallicence zinc protoporphyrin nationallicence Eisenmangel nationallicence Ferritin nationallicence hypochrome Erythrozyten nationallicence löslicher Transferrin-Rezeptor nationallicence Retikulozyten-Hämoglobin nationallicence Zinkprotoporphyrin nationallicence Metzgeroth Georgia III. Medizinische Universitätsklinik, Klinikum Mannheim, Universität Heidelberg, Germany aut Hastka Jan III. Medizinische Universitätsklinik, Klinikum Mannheim, Universität Heidelberg, Germany aut Laboratoriums Medizin Walter de Gruyter 28/5(2004-10-01), 391-399 0342-3026 28:5<391 2004 28 labm https://doi.org/10.1515/LabMed.2004.054 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/LabMed.2004.054 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Metzgeroth Georgia III. Medizinische Universitätsklinik, Klinikum Mannheim, Universität Heidelberg, Germany aut NATIONALLICENCE 700 1- Hastka Jan III. Medizinische Universitätsklinik, Klinikum Mannheim, Universität Heidelberg, Germany aut NATIONALLICENCE 773 0- Laboratoriums Medizin Walter de Gruyter 28/5(2004-10-01), 391-399 0342-3026 28:5<391 2004 28 labm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter