Hydrogels from chitosan crosslinked with poly(ethylene glycol) diacid as bone regeneration materials
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| 024 | 7 | 0 | |a 10.1515/epoly.2004.4.1.643 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/epoly.2004.4.1.643 | ||
| 245 | 0 | 0 | |a Hydrogels from chitosan crosslinked with poly(ethylene glycol) diacid as bone regeneration materials |h [Elektronische Daten] |c [Rosica Mincheva, Nevena Manolova, Rumen Sabov, Galen Kjurkchiev, Iliya Rashkov] |
| 520 | 3 | |a A simple method to covalently crosslink chitosan using poly(ethylene glycol) diacid as crosslinking agent is proposed. Networks net-chitosan-ι- PEG(COOH)2 were obtained by heating chitosan in aqueous PEG600(COOH)2 solutions at a temperature higher than 60°C. IR spectroscopy revealed the formation of amide bonds. It is shown that the obtained chemical networks are pH-sensitive hydrogels with enhanced hydrophilicity. The equilibrium degree of swelling of the hydrogels is determined by the conditions of their preparation - heating temperature and mole ratio between chitosan and the crosslinker. The ability of the polymer networks to facilitate bone regeneration processes was shown by in vivo implantation experiments. | |
| 540 | |a © 2013 by Walter de Gruyter GmbH & Co. | ||
| 700 | 1 | |a Mincheva |D Rosica |u Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria; Fax +359 2 707 523 |4 aut | |
| 700 | 1 | |a Manolova |D Nevena |u Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria; Fax +359 2 707 523 |4 aut | |
| 700 | 1 | |a Sabov |D Rumen |u Medical University, Sv. Georgi Sofiiski str. 3, 1431 Sofia, Bulgaria |4 aut | |
| 700 | 1 | |a Kjurkchiev |D Galen |u Medical University, Sv. Georgi Sofiiski str. 3, 1431 Sofia, Bulgaria |4 aut | |
| 700 | 1 | |a Rashkov |D Iliya |u Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria; Fax +359 2 707 523 |4 aut | |
| 773 | 0 | |t e-Polymers |d De Gruyter |g 4/1(2004-12-01), 643-653 |x 2197-4586 |q 4:1<643 |1 2004 |2 4 |o epoly | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/epoly.2004.4.1.643 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/epoly.2004.4.1.643 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mincheva |D Rosica |u Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria; Fax +359 2 707 523 |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Manolova |D Nevena |u Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria; Fax +359 2 707 523 |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sabov |D Rumen |u Medical University, Sv. Georgi Sofiiski str. 3, 1431 Sofia, Bulgaria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kjurkchiev |D Galen |u Medical University, Sv. Georgi Sofiiski str. 3, 1431 Sofia, Bulgaria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rashkov |D Iliya |u Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria; Fax +359 2 707 523 |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t e-Polymers |d De Gruyter |g 4/1(2004-12-01), 643-653 |x 2197-4586 |q 4:1<643 |1 2004 |2 4 |o epoly | ||
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