Real Dimensions of the Drug Ions from Conductometric Studies of Drugs (Present as Salts) in Acetonitrile
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| 024 | 7 | 0 | |a 10.1524/zpch.218.5.551.30506 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1524/zpch.218.5.551.30506 | ||
| 245 | 0 | 0 | |a Real Dimensions of the Drug Ions from Conductometric Studies of Drugs (Present as Salts) in Acetonitrile |h [Elektronische Daten] |c [R. Mandal, J. Gangopadhyay, S. C. Lahiri] |
| 520 | 3 | |a The Λ0 and association constants of salts of some widely used drugs (pharmacological agents) in acetonitrile have been determined. The division of Λ0 into single ion values λ0+ and λ0− has been made using λ0Na⁺ and λ0Cl⁻ values from the literature. The λ0+ and λ0− values have been found to be considerable in acetonitrile. The results suggest that many of the drugs can be present both as dissociated ions as well as associated molecules which are capable of absorption, dissociation and conduction (of ionic forms) in the lipid layers at very low concentrations. The phenomenon of unsolvation has been utilized to calculate the real dimensions of the drug ions (cations or anions) which are difficult to calculate from bond distances due to their large size and coiled configuration in aqueous solutions. | |
| 540 | |a © 2004 Oldenbourg Wissenschaftsverlag GmbH | ||
| 690 | 7 | |a Thermodynamics & statistical physics |2 nationallicence | |
| 690 | 7 | |a Laboratory techniques, experiments |2 nationallicence | |
| 690 | 7 | |a Physical chemistry |2 nationallicence | |
| 700 | 1 | |a Mandal |D R. |4 aut | |
| 700 | 1 | |a Gangopadhyay |D J. |4 aut | |
| 700 | 1 | |a Lahiri |D S. C. |4 aut | |
| 773 | 0 | |t Zeitschrift für Physikalische Chemie/International journal of research in physical chemistry and chemical physics |d Oldenbourg Wissenschaftsverlag GmbH |g 218/5/2004(2004-05-01), 551-562 |x 0942-9352 |q 218:5/2004<551 |1 2004 |2 218 |o zpch | |
| 856 | 4 | 0 | |u https://doi.org/10.1524/zpch.218.5.551.30506 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1524/zpch.218.5.551.30506 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mandal |D R. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gangopadhyay |D J. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lahiri |D S. C. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Zeitschrift für Physikalische Chemie/International journal of research in physical chemistry and chemical physics |d Oldenbourg Wissenschaftsverlag GmbH |g 218/5/2004(2004-05-01), 551-562 |x 0942-9352 |q 218:5/2004<551 |1 2004 |2 218 |o zpch | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||