caa a22 4500 378904655 CHVBK 20180305123527.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/CCLM.2004.211 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.211 The measurement of complexed prostate-specific antigen has a better performance than total prostate-specific antigen [Elektronische Daten] [Wolfgang Herrmann, Michael Stöckle, Marga Sand-Hill, Ulrich Hübner, Markus Herrmann, Rima Obeid, Bernd Wullich, Tillmann Loch, Jürgen Geisel] The aim of this study was to compare the diagnostic utility of complexed prostate-specific antigen (cPSA) with total PSA (tPSA) in screening for prostate cancer. Serum concentrations of tPSA and cPSA were measured in 4479 adult men during the prostate cancer screening program in the Saarland region (Germany). The percentage of men with c/tPSA ratio above the cut-off value of 0.75 increased with increasing tPSA intervals: tPSA 0-0.9 µg/l, 4.4%; 1.0-1.9 µg/l, 24.3%; 2.0-2.9 µg/l, 43.9%; 3.0-3.9 µg/l, 50.4%; and 4.0-20 µg/l, 60.2%. The commonly accepted tPSA cut-off value of 3.9 µg/l matched to the 93rd percentile of the overall population (corresponding cPSA value, 2.9 µg/l). A total of 202 men out of 313 with increased cPSA had increased c/tPSA ratio (cut-off ≥ 0.75) vs. 186 out of 312 men with increased tPSA. Thus, an additional 16 men at high risk for prostate cancer were selected only if cPSA was utilised as a first line parameter. Our data show that, compared to tPSA, cPSA measurement will always detect more high-risk patients, independent of the cut-off levels utilised for cPSA, tPSA and c/tPSA ratio. cPSA is more effective than tPSA in selecting subjects with an elevated c/tPSA ratio who are at high risk of prostate cancer. Thus, cPSA might be seen as the superior first-line parameter in screening for prostate cancer. Using lower cut-off values for tPSA or cPSA than the commonly accepted values seems reasonable for screening purposes. © Walter de Gruyter Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence cancer of the prostate nationallicence complexed/free prostate-specific antigen ratio nationallicence complexed prostate-specific antigen nationallicence free prostate-specific antigen nationallicence prostate-specific antigen nationallicence screening nationallicence Herrmann Wolfgang Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut Stöckle Michael Department of Urology, University Hospital of Saarland, Homburg/Saar, Germany aut Sand-Hill Marga Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut Hübner Ulrich Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut Herrmann Markus Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut Obeid Rima Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut Wullich Bernd Department of Urology, University Hospital of Saarland, Homburg/Saar, Germany aut Loch Tillmann Department of Urology, University Hospital of Saarland, Homburg/Saar, Germany aut Geisel Jürgen Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/9(2004-09-01), 1051-1057 1434-6621 42:9<1051 2004 42 cclm https://doi.org/10.1515/CCLM.2004.211 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.211 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Herrmann Wolfgang Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Stöckle Michael Department of Urology, University Hospital of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Sand-Hill Marga Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Hübner Ulrich Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Herrmann Markus Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Obeid Rima Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Wullich Bernd Department of Urology, University Hospital of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Loch Tillmann Department of Urology, University Hospital of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 700 1- Geisel Jürgen Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/9(2004-09-01), 1051-1057 1434-6621 42:9<1051 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter