caa a22 4500 378904779 CHVBK 20180305123527.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/CCLM.2004.214 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.214 Evaluation of a new lithium colorimetric assay performed on the Dade Behring Dimension® X-pand™ system [Elektronische Daten] [Damien Gruson, Abdelkrim Lallali, Valérie Furlan, Anne Marie Taburet, Alain Legrand, Marc Conti] Lithium is the standard first line of treatment for bipolar disorder. Because of its potential toxicity, levels of the drug have to be constantly monitored. To this end, an accurate and rapid assay is thus required. Moreover, lithium measurement allows differential diagnosis in patients with hallucinations, dementia and amnesia. The lithium concentration in blood is usually evaluated by flame photometry, atomic absorption spectroscopy or ion selective electrode. The aim of this study was to evaluate the analytical performance of a new colorimetric assay for lithium. Within-day precision of a pool with a target value of 1.25 mmol/l was 2.18% (CV) and day-to-day precision was assessed using serum aliquots containing two concentrations of lithium, and CVs were 5.47 and 1.6% at 0.6 and 1.15 mmol/l, respectively. The lower detection limit (LLD) was <0.08 mmol/l. The assay seemed to be linear up to 5 mmol/l. Results of a comparison method using Deming regression were: y=1.161x-0.0075 (r=0.9879) for regression with the Flame Photometer and y=0.9729 x+0.0133 (r=0.9787) for regression with atomic absorption spectroscopy. Moreover, in this study we did not find any interference with drugs or other analytes tested. In conclusion, this assay may be a method of choice for measuring lithium blood concentrations, especially in emergency situations. © Walter de Gruyter Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence automation nationallicence lithium nationallicence Gruson Damien Laboratoire de Biochimie 1, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut Lallali Abdelkrim Laboratoire de Biochimie 1, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut Furlan Valérie Service de Pharmacie, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut Taburet Anne Marie Service de Pharmacie, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut Legrand Alain Laboratoire de Biochimie 1, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut Conti Marc Laboratoire de Biochimie 1, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/9(2004-09-01), 1066-1068 1434-6621 42:9<1066 2004 42 cclm https://doi.org/10.1515/CCLM.2004.214 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.214 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gruson Damien Laboratoire de Biochimie 1, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut NATIONALLICENCE 700 1- Lallali Abdelkrim Laboratoire de Biochimie 1, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut NATIONALLICENCE 700 1- Furlan Valérie Service de Pharmacie, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut NATIONALLICENCE 700 1- Taburet Anne Marie Service de Pharmacie, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut NATIONALLICENCE 700 1- Legrand Alain Laboratoire de Biochimie 1, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut NATIONALLICENCE 700 1- Conti Marc Laboratoire de Biochimie 1, C.H.U de Bicêtre, AP-HP, Le Kremlin Bicêtre, France aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/9(2004-09-01), 1066-1068 1434-6621 42:9<1066 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter