caa a22 4500 378904825 CHVBK 20180305123527.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/CCLM.2004.212 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.212 Effect of prolonged physical exercise on urinary proANP1-30 and proANP31-67 [Elektronische Daten] [Enrico Cappellin, Elio F. De Palo, Rosalba Gatti, Giuseppe Soldà, Wolfgang Woloszczuk, Paolo Spinella] Dynamic exercise strongly affects atrial natriuretic peptides (ANP), in particular the mature bioactive αANP and the proANP fragments, namely proANP1-98, proANP1-30 and proANP31-67. The proANPs influence kidney functions and their plasma levels increase after physical exercise. We measured urinary proANP1-30 and proANP31-67 levels before and at the end of physical exercise in 28 well-trained male cyclists. For the first time, the proANP1-30 and proANP31-67 urinary levels in athletes before and at the end of a prolonged agonistic bicycle race were measured. Urinary creatinine and total proteins were also measured. The urinary proANP31-67, creatinine and total protein levels were significantly higher at the end of exercise than before. In contrast, proANP1-30/protein and proANP31-67/protein ratios decreased after exercise. Even proANP1-30/creatinine and proANP31-67/creatinine ratios were lower after exercise. A significant correlation between proANP1-30 and proANP31-67 urinary levels at the end of exercise was found. The proANP31-67/creatinine ratio before and after exercise also showed a significant correlation. The variation of urinary proANP fragments confirmed their possible role in physical exercise. In particular, it could be interpreted as a response of the body or kidney to renal impairment occurring during exercise. © Walter de Gruyter Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence atrial natriuretic peptide nationallicence kidney nationallicence physical exercise nationallicence proteinuria nationallicence Cappellin Enrico Clinical Biochemistry Section, Department of Medical Diagnostic Sciences and Spec. Ther., University of Padua, Padua Italy; Geriatric Division of ULSS 15, Camposampiero PD, Italy aut De Palo Elio F. Clinical Biochemistry Section, Department of Medical Diagnostic Sciences and Spec. Ther., University of Padua, Padua, Italy aut Gatti Rosalba Clinical Biochemistry Section, Department of Medical Diagnostic Sciences and Spec. Ther., University of Padua and Azienda Ospedaliera di Padova, Padua, Italy aut Soldà Giuseppe Geriatric Division of ULSS 15, Camposampiero PD, Italy aut Woloszczuk Wolfgang Ludwig Boltzmann Institut für Experimentelle Endokrinologie Vienna, Austria aut Spinella Paolo Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Padua, Padua, Italy aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/9(2004-09-01), 1058-1062 1434-6621 42:9<1058 2004 42 cclm https://doi.org/10.1515/CCLM.2004.212 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.212 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cappellin Enrico Clinical Biochemistry Section, Department of Medical Diagnostic Sciences and Spec. Ther., University of Padua, Padua Italy; Geriatric Division of ULSS 15, Camposampiero PD, Italy aut NATIONALLICENCE 700 1- De Palo Elio F. Clinical Biochemistry Section, Department of Medical Diagnostic Sciences and Spec. Ther., University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Gatti Rosalba Clinical Biochemistry Section, Department of Medical Diagnostic Sciences and Spec. Ther., University of Padua and Azienda Ospedaliera di Padova, Padua, Italy aut NATIONALLICENCE 700 1- Soldà Giuseppe Geriatric Division of ULSS 15, Camposampiero PD, Italy aut NATIONALLICENCE 700 1- Woloszczuk Wolfgang Ludwig Boltzmann Institut für Experimentelle Endokrinologie Vienna, Austria aut NATIONALLICENCE 700 1- Spinella Paolo Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Padua, Padua, Italy aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/9(2004-09-01), 1058-1062 1434-6621 42:9<1058 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter