caa a22 4500 37890485X CHVBK 20180305123527.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/2004.206 doi (NATIONALLICENCE)gruyter-10.1515/2004.206 Comparison of cardiac troponin T and I in healthy men and in aortic valve replacement [Elektronische Daten] [Eberhard Gurr, Knut Leitz] Troponins are of outstanding importance for the diagnosis of myocardial infarction. Cardiac troponin T (cTnT) and the various cardiac troponin I (cTnI) assays differ with respect to method comparison, diagnostic sensitivity and diagnostic specificity. To understand the differences in the diagnostic behavior of troponin assays, AccuTnI and Elecsys Troponin STAT were used in a group of healthy men and in the follow-up of patients with aortic valve replacement (AVR). Within the healthy subjects AccuTnI was able to differentiate two subgroups from each other, whereas the cTnT concentrations of all subjects were below the detection limit. In AVR patients, cTnT and cTnI correlated sufficiently, if the postoperative periods were taken into consideration. There was a rapid increase in cTnI within 24 h. In contrast, a broad peak was evident for cTnT between 48 and 120 h. The results emphasize more the differences in the release of cTnI and cTnT from the cytoplasm and the thin filaments of the cardiomyocytes than the modifications of the troponins circulating in the blood. © Walter de Gruyter Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence aortic valve replacement nationallicence method comparison nationallicence reference range nationallicence troponin I nationallicence troponin T nationallicence Gurr Eberhard Department of Clinical Chemistry, Zentralkrankenhaus Links der Weser, Bremen, Germany aut Leitz Knut Clinic of Thoracic, Heart and Vascular Surgery, Zentralkrankenhaus Links der Weser, Bremen, Germany aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/9(2004-09-01), 1020-1026 1434-6621 42:9<1020 2004 42 cclm https://doi.org/10.1515/2004.206 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/2004.206 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gurr Eberhard Department of Clinical Chemistry, Zentralkrankenhaus Links der Weser, Bremen, Germany aut NATIONALLICENCE 700 1- Leitz Knut Clinic of Thoracic, Heart and Vascular Surgery, Zentralkrankenhaus Links der Weser, Bremen, Germany aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/9(2004-09-01), 1020-1026 1434-6621 42:9<1020 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter