caa a22 4500 378907093 CHVBK 20180305123532.0 cr unu---uuuuu 161128e20040401xx s 000 0 eng 10.1524/ract.92.4.219.35608 doi (NATIONALLICENCE)gruyter-10.1524/ract.92.4.219.35608 The Auger-electron emitter 165Er: excitation function of the 165Ho(p,n)165Er process [Elektronische Daten] [G. J. Beyer, S. K. Zeisler, D. W. Becker] The lanthanide isotope 165Er decays by electron capture without any accompanying gamma radiation, which makes it an ideal radionuclide for Auger electron therapy. The chemical properties of erbium with regard to labelling of bio-conjugates are virtually identical to those of radio-yttrium. We measured the excitation function of the 165Ho(p,n) 165Er reaction and obtained a maximum cross section of 166±20mb at 11.1±0.5MeV proton energy. Our findings indicate that 165Er can be produced at any small-sized cyclotron in quantities suitable for biomedical applications. The thick target yield at Ep=15MeV is 55MBq/μA h. A mass separated sample of the nuclide pair 160Er/160Ho was used as model to demonstrate that the separation of the 165Er from the target matrix material Ho can be achieved by cation-exchange chromatography using Aminex A5 resin and α-HIBA as eluent in about 1hour. © 2004 Oldenbourg Wissenschaftsverlag GmbH Laboratory techniques, experiments nationallicence Analytical chemistry nationallicence Inorganic chemistry nationallicence Beyer G. J. aut Zeisler S. K. aut Becker D. W. aut Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/4-6/2004(2004-04-01), 219-222 0033-8230 92:4-6/2004<219 2004 92 ract https://doi.org/10.1524/ract.92.4.219.35608 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1524/ract.92.4.219.35608 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beyer G. J. aut NATIONALLICENCE 700 1- Zeisler S. K. aut NATIONALLICENCE 700 1- Becker D. W. aut NATIONALLICENCE 773 0- Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/4-6/2004(2004-04-01), 219-222 0033-8230 92:4-6/2004<219 2004 92 ract CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter