Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 378907115 | ||
| 003 | CHVBK | ||
| 005 | 20180305123532.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 161128e20040401xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1524/ract.92.4.311.35595 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1524/ract.92.4.311.35595 | ||
| 245 | 0 | 0 | |a Radioiodination of ammonio-closo-monocarborane, 1-H3N-1-CB11H11. Aspects of labelling chemistry in aqueous solution using Chloramine-T |h [Elektronische Daten] |c [Anna Orlova, Igor Sivaev, Stefan Sjöberg, Hans Lundqvist, Vladimir Tolmachev] |
| 520 | 3 | |a The aim of this study was to investigate the use of electrophilic radioiodination in the labelling of closo-monocarborane(-1). Ammonio-closo-monocarborane (ACMC, 1NH31CB11H11) was labelled with 125I using Chloramine-T as an oxidant. Radio-TLC was used for analysis. Influence of substrate amount, oxidant concentration, and pH of the reaction media on the labelling yield was studied. A labelling yield of 80%-90% was obtained. The results of the study indicate feasibility to use derivatives of closo-monocarborane(-1) as a pendant group for indirect radioiodination of proteins, and for studying pharmacokinetics of boron-rich compounds for BNCT. | |
| 540 | |a © 2004 Oldenbourg Wissenschaftsverlag GmbH | ||
| 690 | 7 | |a Laboratory techniques, experiments |2 nationallicence | |
| 690 | 7 | |a Analytical chemistry |2 nationallicence | |
| 690 | 7 | |a Inorganic chemistry |2 nationallicence | |
| 700 | 1 | |a Orlova |D Anna |4 aut | |
| 700 | 1 | |a Sivaev |D Igor |4 aut | |
| 700 | 1 | |a Sjöberg |D Stefan |4 aut | |
| 700 | 1 | |a Lundqvist |D Hans |4 aut | |
| 700 | 1 | |a Tolmachev |D Vladimir |4 aut | |
| 773 | 0 | |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/4-6/2004(2004-04-01), 311-315 |x 0033-8230 |q 92:4-6/2004<311 |1 2004 |2 92 |o ract | |
| 856 | 4 | 0 | |u https://doi.org/10.1524/ract.92.4.311.35595 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1524/ract.92.4.311.35595 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Orlova |D Anna |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sivaev |D Igor |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sjöberg |D Stefan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lundqvist |D Hans |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tolmachev |D Vladimir |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/4-6/2004(2004-04-01), 311-315 |x 0033-8230 |q 92:4-6/2004<311 |1 2004 |2 92 |o ract | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||