Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
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| 024 | 7 | 0 | |a 10.1524/ract.92.4.209.35593 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1524/ract.92.4.209.35593 | ||
| 245 | 0 | 0 | |a Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM |h [Elektronische Daten] |c [Toshimitsu Fukumura, Kazuhiro Okada, Ferenc Szelecsényi, Zoltán Kovács, Kazutoshi Suzuki] |
| 520 | 3 | |a Copper-61 (T1/2=3.41h) produced via the 59Co(α,2n)61Cu nuclear reaction using natural Co target was isolated from the irradiated target by two methods developed here and applied for preparation of (61Cu-ATSM) (61Cu-diacetyl-bis(N4-methylthiosemicarbazone)), known as an imaging agent of hypoxic tissue. A commercially available cobalt disk (thickness: 125μm) was irradiated with 40MeV (37.9MeV on target) α particles, then treated with conc. HNO3, and the 61Cu was separated by two different methods, i.e. a two column method using a cation and an anion exchange column; and a one column method using a column packed with chelating resin, Chelex 100. Both separation methods gave satisfactory results, though the latter method was superior because of the simplicity of the apparatus, the separation procedure and somewhat shorter processing time. Around 1.1GBq of 61Cu2+ were obtained with >95% yield (decay corrected) from Co target at 10μA for 1h irradiation, and with the radionuclidic purity of >98% (EOS). The only radionuclidic impurity in the isolated 61Cu2+ solution was identified to be 60Cu at EOS but no radionuclidic impurity was observed after 50hours. The solution of 61Cu-ATSM was prepared in >85% radiochemical yield with >95% radiochemical purity. | |
| 540 | |a © 2004 Oldenbourg Wissenschaftsverlag GmbH | ||
| 690 | 7 | |a Laboratory techniques, experiments |2 nationallicence | |
| 690 | 7 | |a Analytical chemistry |2 nationallicence | |
| 690 | 7 | |a Inorganic chemistry |2 nationallicence | |
| 700 | 1 | |a Fukumura |D Toshimitsu |4 aut | |
| 700 | 1 | |a Okada |D Kazuhiro |4 aut | |
| 700 | 1 | |a Szelecsényi |D Ferenc |4 aut | |
| 700 | 1 | |a Kovács |D Zoltán |4 aut | |
| 700 | 1 | |a Suzuki |D Kazutoshi |4 aut | |
| 773 | 0 | |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/4-6/2004(2004-04-01), 209-214 |x 0033-8230 |q 92:4-6/2004<209 |1 2004 |2 92 |o ract | |
| 856 | 4 | 0 | |u https://doi.org/10.1524/ract.92.4.209.35593 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1524/ract.92.4.209.35593 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fukumura |D Toshimitsu |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okada |D Kazuhiro |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Szelecsényi |D Ferenc |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kovács |D Zoltán |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Suzuki |D Kazutoshi |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/4-6/2004(2004-04-01), 209-214 |x 0033-8230 |q 92:4-6/2004<209 |1 2004 |2 92 |o ract | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||