caa a22 4500 378907328 CHVBK 20180305123533.0 cr unu---uuuuu 161128e20040401xx s 000 0 eng 10.1524/ract.92.4.341.35597 doi (NATIONALLICENCE)gruyter-10.1524/ract.92.4.341.35597 Determination of reaction parameters for the synthesis of the serotonin transporter ligand [11C]DASB: Application to a remotely controlled high yield synthesis [Elektronische Daten] [C. Solbach, G. Reischl, H.-J. Machulla] The synthesis of [11C]DASB is known to be performed by reacting the demethyl-DASB precursor with [11C]methyl iodide but the necessary reaction parameters had hitherto not been determined. In this work the dependence of the labelling yield on reaction temperature, reaction time, precursor concentration and type of solvent was investigated. Best results were found when methylation was carried out at 100°C within 2min using 4mg/ml demethyl precursor in DMSO. With respect to [11C]methyl iodide a radiochemical yield of 74%±3% [11C]DASB was achieved. In addition, the synthesis was transferred to a remotely controlled module. A carbon-11 production for 1h at 50μA resulted in 3800-4300MBq [11C]DASB with a specific activity of 152-211GBq/μmol (4.1-5.7Ci/μmol) (EOS) and a radiochemical purity of >95% in a sterile solution ready for injection. The total synthesis time was 45min after EOB. © 2004 Oldenbourg Wissenschaftsverlag GmbH Laboratory techniques, experiments nationallicence Analytical chemistry nationallicence Inorganic chemistry nationallicence Solbach C. aut Reischl G. aut Machulla H.-J aut Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/4-6/2004(2004-04-01), 341-344 0033-8230 92:4-6/2004<341 2004 92 ract https://doi.org/10.1524/ract.92.4.341.35597 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1524/ract.92.4.341.35597 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Solbach C. aut NATIONALLICENCE 700 1- Reischl G. aut NATIONALLICENCE 700 1- Machulla H.-J aut NATIONALLICENCE 773 0- Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/4-6/2004(2004-04-01), 341-344 0033-8230 92:4-6/2004<341 2004 92 ract CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter