Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding
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| 024 | 7 | 0 | |a 10.1524/ract.92.4.333.35584 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1524/ract.92.4.333.35584 | ||
| 245 | 0 | 0 | |a Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding |h [Elektronische Daten] |c [Stephen M. Moerlein, Joel S. Perlmutter, Michael J. Welch] |
| 520 | 3 | |a A procedure for the reliable production of the novel PET D2 receptor ligand (N-[11C]methyl)benperidol ([11C]NMB) is described. The method is based on N-methylation of benperidol using [11C]methyl iodide from the PETtrace MeI MicroLab, with product purification via normal-phase HPLC. Batch yields of 2.5±0.9GBq (68±25mCi) of [11C]NMB are routinely (n=16) obtained, with a radiochemical purity >98% and an average specific activity of over 40.7TBq (1100Ci)/mmol. The overall radiosynthesis, purification, and pre-release quality control testing is accomplished within 50minutes. The procedure described herein produces a radiopharmaceutical product that is suitable for D2 receptor studies using PET or microPET imaging. | |
| 540 | |a © 2004 Oldenbourg Wissenschaftsverlag GmbH | ||
| 690 | 7 | |a Laboratory techniques, experiments |2 nationallicence | |
| 690 | 7 | |a Analytical chemistry |2 nationallicence | |
| 690 | 7 | |a Inorganic chemistry |2 nationallicence | |
| 700 | 1 | |a Moerlein |D Stephen M. |4 aut | |
| 700 | 1 | |a Perlmutter |D Joel S. |4 aut | |
| 700 | 1 | |a Welch |D Michael J. |4 aut | |
| 773 | 0 | |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/4-6/2004(2004-04-01), 333-339 |x 0033-8230 |q 92:4-6/2004<333 |1 2004 |2 92 |o ract | |
| 856 | 4 | 0 | |u https://doi.org/10.1524/ract.92.4.333.35584 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1524/ract.92.4.333.35584 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Moerlein |D Stephen M. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Perlmutter |D Joel S. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Welch |D Michael J. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/4-6/2004(2004-04-01), 333-339 |x 0033-8230 |q 92:4-6/2004<333 |1 2004 |2 92 |o ract | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||