caa a22 4500 378907336 CHVBK 20180305123533.0 cr unu---uuuuu 161128e20040401xx s 000 0 eng 10.1524/ract.92.4.333.35584 doi (NATIONALLICENCE)gruyter-10.1524/ract.92.4.333.35584 Radiosynthesis of (N-[11C]methyl)benperidol for PET investigation of D2 receptor binding [Elektronische Daten] [Stephen M. Moerlein, Joel S. Perlmutter, Michael J. Welch] A procedure for the reliable production of the novel PET D2 receptor ligand (N-[11C]methyl)benperidol ([11C]NMB) is described. The method is based on N-methylation of benperidol using [11C]methyl iodide from the PETtrace MeI MicroLab, with product purification via normal-phase HPLC. Batch yields of 2.5±0.9GBq (68±25mCi) of [11C]NMB are routinely (n=16) obtained, with a radiochemical purity >98% and an average specific activity of over 40.7TBq (1100Ci)/mmol. The overall radiosynthesis, purification, and pre-release quality control testing is accomplished within 50minutes. The procedure described herein produces a radiopharmaceutical product that is suitable for D2 receptor studies using PET or microPET imaging. © 2004 Oldenbourg Wissenschaftsverlag GmbH Laboratory techniques, experiments nationallicence Analytical chemistry nationallicence Inorganic chemistry nationallicence Moerlein Stephen M. aut Perlmutter Joel S. aut Welch Michael J. aut Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/4-6/2004(2004-04-01), 333-339 0033-8230 92:4-6/2004<333 2004 92 ract https://doi.org/10.1524/ract.92.4.333.35584 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1524/ract.92.4.333.35584 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moerlein Stephen M. aut NATIONALLICENCE 700 1- Perlmutter Joel S. aut NATIONALLICENCE 700 1- Welch Michael J. aut NATIONALLICENCE 773 0- Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/4-6/2004(2004-04-01), 333-339 0033-8230 92:4-6/2004<333 2004 92 ract CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter