Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine
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| 024 | 7 | 0 | |a 10.1524/ract.92.4.271.35612 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1524/ract.92.4.271.35612 | ||
| 245 | 0 | 0 | |a Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine |h [Elektronische Daten] |c [Bernhard Noll, Christoph S. Hilger, Peter Leibnitz, Hartmut Spies] |
| 520 | 3 | |a Bifunctional ligands able to form neutral complexes with radioactive technetium and rhenium and to couple to biological relevant anchor groups play an important role in the design of new radiopharmaceuticals for diagnosis and therapy. A novel tetradentate amide thioether dithiolate ligand HS-CH2CH2-S-CH2CONH-CH(COOR)CH2SH (H3SNSS) with R=CH3, C10H21 was synthesized that forms stable complexes with technetium and rhenium in oxidation state V. The molecular structures of the rhenium and technetium complexes MO(SNSS) were determined by X-ray structural analysis and show that the metal coordination number is five and the coordination polyhedron is between square-pyramidal and trigonal-bipyramidal. The pendent ester group allows coupling of the chelate unit at biologically relevant anchor groups. As a relevant representative the X-ray structural analysis of the rhenium decylester complex was carried out. The complex formation with Tc at the n.c.a. level and 186Re at 10-6M level is described. | |
| 540 | |a © 2004 Oldenbourg Wissenschaftsverlag GmbH | ||
| 690 | 7 | |a Laboratory techniques, experiments |2 nationallicence | |
| 690 | 7 | |a Analytical chemistry |2 nationallicence | |
| 690 | 7 | |a Inorganic chemistry |2 nationallicence | |
| 700 | 1 | |a Noll |D Bernhard |4 aut | |
| 700 | 1 | |a Hilger |D Christoph S. |4 aut | |
| 700 | 1 | |a Leibnitz |D Peter |4 aut | |
| 700 | 1 | |a Spies |D Hartmut |4 aut | |
| 773 | 0 | |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/4-6/2004(2004-04-01), 271-276 |x 0033-8230 |q 92:4-6/2004<271 |1 2004 |2 92 |o ract | |
| 856 | 4 | 0 | |u https://doi.org/10.1524/ract.92.4.271.35612 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1524/ract.92.4.271.35612 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Noll |D Bernhard |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hilger |D Christoph S. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Leibnitz |D Peter |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Spies |D Hartmut |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Radiochimica Acta/International journal for chemical aspects of nuclear science and technology |d Oldenbourg Wissenschaftsverlag GmbH |g 92/4-6/2004(2004-04-01), 271-276 |x 0033-8230 |q 92:4-6/2004<271 |1 2004 |2 92 |o ract | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||