caa a22 4500 378907344 CHVBK 20180305123533.0 cr unu---uuuuu 161128e20040401xx s 000 0 eng 10.1524/ract.92.4.271.35612 doi (NATIONALLICENCE)gruyter-10.1524/ract.92.4.271.35612 Neutral oxorhenium(V) and oxotechnetium(V) complexes with novel amide thioether dithiolate ligands derived from cysteine [Elektronische Daten] [Bernhard Noll, Christoph S. Hilger, Peter Leibnitz, Hartmut Spies] Bifunctional ligands able to form neutral complexes with radioactive technetium and rhenium and to couple to biological relevant anchor groups play an important role in the design of new radiopharmaceuticals for diagnosis and therapy. A novel tetradentate amide thioether dithiolate ligand HS-CH2CH2-S-CH2CONH-CH(COOR)CH2SH (H3SNSS) with R=CH3, C10H21 was synthesized that forms stable complexes with technetium and rhenium in oxidation state V. The molecular structures of the rhenium and technetium complexes MO(SNSS) were determined by X-ray structural analysis and show that the metal coordination number is five and the coordination polyhedron is between square-pyramidal and trigonal-bipyramidal. The pendent ester group allows coupling of the chelate unit at biologically relevant anchor groups. As a relevant representative the X-ray structural analysis of the rhenium decylester complex was carried out. The complex formation with Tc at the n.c.a. level and 186Re at 10-6M level is described. © 2004 Oldenbourg Wissenschaftsverlag GmbH Laboratory techniques, experiments nationallicence Analytical chemistry nationallicence Inorganic chemistry nationallicence Noll Bernhard aut Hilger Christoph S. aut Leibnitz Peter aut Spies Hartmut aut Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/4-6/2004(2004-04-01), 271-276 0033-8230 92:4-6/2004<271 2004 92 ract https://doi.org/10.1524/ract.92.4.271.35612 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1524/ract.92.4.271.35612 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Noll Bernhard aut NATIONALLICENCE 700 1- Hilger Christoph S. aut NATIONALLICENCE 700 1- Leibnitz Peter aut NATIONALLICENCE 700 1- Spies Hartmut aut NATIONALLICENCE 773 0- Radiochimica Acta/International journal for chemical aspects of nuclear science and technology Oldenbourg Wissenschaftsverlag GmbH 92/4-6/2004(2004-04-01), 271-276 0033-8230 92:4-6/2004<271 2004 92 ract CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter