Discovery of new anti-inflammatory agents
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| 024 | 7 | 0 | |a 10.1351/pac200476050965 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1351/pac200476050965 | ||
| 245 | 0 | 0 | |a Discovery of new anti-inflammatory agents |h [Elektronische Daten] |c [F. Fülöp, László Lázár, Z. Szakonyi, M. Pihlavisto, Sakari Alaranta, P. J. Vainio, Auni Juhakoski, Anne Marjamäki, D. J. Smith] |
| 520 | 3 | |a We have synthesized a series of novel hydrazines and hydrazino alcohols that specifically inhibit vascular adhesion protein-1 (VAP-1), a human endothelial cell adhesion molecule with a well documented role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase (SSAO), and the enzyme activity has been demonstrated to have a role in VAP-1 function. An indane hydrazino alcohol was able to reduce clinical symptoms of inflammation in experimental arthritis in rodents and has the potential to be a novel anti-inflammatory drug. | |
| 540 | |a © 2013 Walter de Gruyter GmbH, Berlin/Boston | ||
| 700 | 1 | |a Fülöp |D F. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | |
| 700 | 1 | |a Lázár |D László |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | |
| 700 | 1 | |a Szakonyi |D Z. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | |
| 700 | 1 | |a Pihlavisto |D M. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | |
| 700 | 1 | |a Alaranta |D Sakari |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | |
| 700 | 1 | |a Vainio |D P. J. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | |
| 700 | 1 | |a Juhakoski |D Auni |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | |
| 700 | 1 | |a Marjamäki |D Anne |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | |
| 700 | 1 | |a Smith |D D. J. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | |
| 773 | 0 | |t Pure and Applied Chemistry |d De Gruyter |g 76/5(2004-01-01), 965-972 |x 0033-4545 |q 76:5<965 |1 2004 |2 76 |o pac | |
| 856 | 4 | 0 | |u https://doi.org/10.1351/pac200476050965 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1351/pac200476050965 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fülöp |D F. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lázár |D László |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Szakonyi |D Z. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pihlavisto |D M. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Alaranta |D Sakari |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vainio |D P. J. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Juhakoski |D Auni |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Marjamäki |D Anne |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Smith |D D. J. |u Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Pure and Applied Chemistry |d De Gruyter |g 76/5(2004-01-01), 965-972 |x 0033-4545 |q 76:5<965 |1 2004 |2 76 |o pac | ||
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