caa a22 4500 378911236 CHVBK 20180305123542.0 cr unu---uuuuu 161128e20040101xx s 000 0 eng 10.1351/pac200476050965 doi (NATIONALLICENCE)gruyter-10.1351/pac200476050965 Discovery of new anti-inflammatory agents [Elektronische Daten] [F. Fülöp, László Lázár, Z. Szakonyi, M. Pihlavisto, Sakari Alaranta, P. J. Vainio, Auni Juhakoski, Anne Marjamäki, D. J. Smith] We have synthesized a series of novel hydrazines and hydrazino alcohols that specifically inhibit vascular adhesion protein-1 (VAP-1), a human endothelial cell adhesion molecule with a well documented role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase (SSAO), and the enzyme activity has been demonstrated to have a role in VAP-1 function. An indane hydrazino alcohol was able to reduce clinical symptoms of inflammation in experimental arthritis in rodents and has the potential to be a novel anti-inflammatory drug. © 2013 Walter de Gruyter GmbH, Berlin/Boston Fülöp F. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut Lázár László Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut Szakonyi Z. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut Pihlavisto M. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut Alaranta Sakari Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut Vainio P. J. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut Juhakoski Auni Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut Marjamäki Anne Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut Smith D. J. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut Pure and Applied Chemistry De Gruyter 76/5(2004-01-01), 965-972 0033-4545 76:5<965 2004 76 pac https://doi.org/10.1351/pac200476050965 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476050965 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fülöp F. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut NATIONALLICENCE 700 1- Lázár László Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut NATIONALLICENCE 700 1- Szakonyi Z. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut NATIONALLICENCE 700 1- Pihlavisto M. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut NATIONALLICENCE 700 1- Alaranta Sakari Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut NATIONALLICENCE 700 1- Vainio P. J. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut NATIONALLICENCE 700 1- Juhakoski Auni Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut NATIONALLICENCE 700 1- Marjamäki Anne Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut NATIONALLICENCE 700 1- Smith D. J. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies Corporation, Tykistökatu 6, FIN-20520 Turku, Finland aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/5(2004-01-01), 965-972 0033-4545 76:5<965 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter