caa a22 4500 378911279 CHVBK 20180305123542.0 cr unu---uuuuu 161128e20040101xx s 000 0 eng 10.1351/pac200476050959 doi (NATIONALLICENCE)gruyter-10.1351/pac200476050959 Spacer conformation in biologically active molecules [Elektronische Daten] [J. Karolak-Wojciechowska, A. Fruzinski] Based on our contemporary studies on the structures of biologically active molecules, we focus our attention on the aliphatic chain and its conformation. That flexible spacer definitely influenced the balanced position of all pharmacophoric points in molecules of biological ligands. The one atomic linker and two or three atomic spacers with one heteroatom X =O, S, CH2, NH have been taken into account. The conformational preferences clearly depend on the heteroatom X. In the discussion, we utilize our own X-ray data, computation chemistry methods, population analysis, and statistical data from the Cambridge Structural Database (CSD). © 2013 Walter de Gruyter GmbH, Berlin/Boston Karolak-Wojciechowska J. Institute of General and Ecological Chemistry, Technical University, Lódz , Poland aut Fruzinski A. Institute of General and Ecological Chemistry, Technical University, Lódz , Poland aut Pure and Applied Chemistry De Gruyter 76/5(2004-01-01), 959-964 0033-4545 76:5<959 2004 76 pac https://doi.org/10.1351/pac200476050959 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476050959 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karolak-Wojciechowska J. Institute of General and Ecological Chemistry, Technical University, Lódz , Poland aut NATIONALLICENCE 700 1- Fruzinski A. Institute of General and Ecological Chemistry, Technical University, Lódz , Poland aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/5(2004-01-01), 959-964 0033-4545 76:5<959 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter