Development of modulators of multidrug resistance: A pharmacoinformatic approach
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| 005 | 20180305123542.0 | ||
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| 008 | 161128e20040101xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1351/pac200476050997 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1351/pac200476050997 | ||
| 245 | 0 | 0 | |a Development of modulators of multidrug resistance: A pharmacoinformatic approach |h [Elektronische Daten] |c [G. F. Ecker, Peter Chiba] |
| 520 | 3 | |a Inhibition of drug efflux pumps such as P-glycoprotein represents a versatile approach for overcoming multidrug resistance in tumor therapy. Although numerous compounds have been identified as being able to inhibit P-glycoprotein, only little is known on the molecular basis of the drug-protein interaction. This article gives an overview of the different pharmacoinformatic approaches we used to develop new propafenone-type modulators of P-glycoprotein. These include 2D-and 3D-QSAR studies, artificial neural networks, and photoaffinity labeling studies. | |
| 540 | |a © 2013 Walter de Gruyter GmbH, Berlin/Boston | ||
| 700 | 1 | |a Ecker |D G. F. |u Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Wien, Austria; Department of Medical Chemistry, Medical University of Vienna, Waehringer Strasse 10, 1090 Wien, Austria |4 aut | |
| 700 | 1 | |a Chiba |D Peter |u Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Wien, Austria; Department of Medical Chemistry, Medical University of Vienna, Waehringer Strasse 10, 1090 Wien, Austria |4 aut | |
| 773 | 0 | |t Pure and Applied Chemistry |d De Gruyter |g 76/5(2004-01-01), 997-1005 |x 0033-4545 |q 76:5<997 |1 2004 |2 76 |o pac | |
| 856 | 4 | 0 | |u https://doi.org/10.1351/pac200476050997 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1351/pac200476050997 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ecker |D G. F. |u Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Wien, Austria; Department of Medical Chemistry, Medical University of Vienna, Waehringer Strasse 10, 1090 Wien, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chiba |D Peter |u Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Wien, Austria; Department of Medical Chemistry, Medical University of Vienna, Waehringer Strasse 10, 1090 Wien, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Pure and Applied Chemistry |d De Gruyter |g 76/5(2004-01-01), 997-1005 |x 0033-4545 |q 76:5<997 |1 2004 |2 76 |o pac | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||