Solid- and solution-phase synthesis of bioactive dihydropyrimidines
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| 001 | 378911333 | ||
| 003 | CHVBK | ||
| 005 | 20180305123542.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 161128e20040101xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1351/pac200476051017 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1351/pac200476051017 | ||
| 245 | 0 | 0 | |a Solid- and solution-phase synthesis of bioactive dihydropyrimidines |h [Elektronische Daten] |c [Doris Dallinger, A. Stadler, C. O. Kappe] |
| 520 | 3 | |a With the emergence of high-throughput screening in the pharmaceutical industry over a decade ago, synthetic chemists were faced with the challenge of preparing large collections of molecules to satisfy the demand for new screening compounds. The unique exploratory power of multicomponent reactions such as the Biginelli three-component reaction was soon recognized to be extremely valuable to produce compound libraries in a time- and cost-effective manner. The present review summarizes synthetic advances from our laboratories for the construction of Biginelli libraries via solution-and solid-phase strategies that are amenable to a high-throughput or combinatorial format. | |
| 540 | |a © 2013 Walter de Gruyter GmbH, Berlin/Boston | ||
| 700 | 1 | |a Dallinger |D Doris |u Institute of Chemistry, Karl-Franzens-University Graz, Austria |4 aut | |
| 700 | 1 | |a Stadler |D A. |u Institute of Chemistry, Karl-Franzens-University Graz, Austria |4 aut | |
| 700 | 1 | |a Kappe |D C. O. |u Institute of Chemistry, Karl-Franzens-University Graz, Austria |4 aut | |
| 773 | 0 | |t Pure and Applied Chemistry |d De Gruyter |g 76/5(2004-01-01), 1017-1024 |x 0033-4545 |q 76:5<1017 |1 2004 |2 76 |o pac | |
| 856 | 4 | 0 | |u https://doi.org/10.1351/pac200476051017 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1351/pac200476051017 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dallinger |D Doris |u Institute of Chemistry, Karl-Franzens-University Graz, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stadler |D A. |u Institute of Chemistry, Karl-Franzens-University Graz, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kappe |D C. O. |u Institute of Chemistry, Karl-Franzens-University Graz, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Pure and Applied Chemistry |d De Gruyter |g 76/5(2004-01-01), 1017-1024 |x 0033-4545 |q 76:5<1017 |1 2004 |2 76 |o pac | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||