caa a22 4500 378911333 CHVBK 20180305123542.0 cr unu---uuuuu 161128e20040101xx s 000 0 eng 10.1351/pac200476051017 doi (NATIONALLICENCE)gruyter-10.1351/pac200476051017 Solid- and solution-phase synthesis of bioactive dihydropyrimidines [Elektronische Daten] [Doris Dallinger, A. Stadler, C. O. Kappe] With the emergence of high-throughput screening in the pharmaceutical industry over a decade ago, synthetic chemists were faced with the challenge of preparing large collections of molecules to satisfy the demand for new screening compounds. The unique exploratory power of multicomponent reactions such as the Biginelli three-component reaction was soon recognized to be extremely valuable to produce compound libraries in a time- and cost-effective manner. The present review summarizes synthetic advances from our laboratories for the construction of Biginelli libraries via solution-and solid-phase strategies that are amenable to a high-throughput or combinatorial format. © 2013 Walter de Gruyter GmbH, Berlin/Boston Dallinger Doris Institute of Chemistry, Karl-Franzens-University Graz, Austria aut Stadler A. Institute of Chemistry, Karl-Franzens-University Graz, Austria aut Kappe C. O. Institute of Chemistry, Karl-Franzens-University Graz, Austria aut Pure and Applied Chemistry De Gruyter 76/5(2004-01-01), 1017-1024 0033-4545 76:5<1017 2004 76 pac https://doi.org/10.1351/pac200476051017 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476051017 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dallinger Doris Institute of Chemistry, Karl-Franzens-University Graz, Austria aut NATIONALLICENCE 700 1- Stadler A. Institute of Chemistry, Karl-Franzens-University Graz, Austria aut NATIONALLICENCE 700 1- Kappe C. O. Institute of Chemistry, Karl-Franzens-University Graz, Austria aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/5(2004-01-01), 1017-1024 0033-4545 76:5<1017 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter