caa a22 4500 378916149 CHVBK 20180305123553.0 cr unu---uuuuu 161128e20040105xx s 000 0 eng 10.1515/BC.2004.001 doi (NATIONALLICENCE)gruyter-10.1515/BC.2004.001 The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations [Elektronische Daten] [L. A. Ridnour, D. D. Thomas, D. Mancardi, M. G. Espey, K. M. Miranda, N. Paolocci, M. Feelisch, J. Fukuto, D. A. Wink] This review addresses many of the chemical aspects of nitrosative stress mediated by N(2)O(3). From a cellular perspective, N(2)O(3) and the resulting reactive nitrogen oxide species target specific motifs such as thiols, lysine active sites, and zinc fingers and is dependant upon both the rates of production as well as consumption of NO and must be taken into account in order to access the nitrosative environment. Since production and consumption are integral parts of N(2)O(3) generation, we predict that nitrosative stress occurs under specific conditions, such as chronic inflammation. In contrast to conditions of stress, nitrosative chemistry may also provide cellular protection through the regulation of critical signaling pathways. Therefore, a careful evaluation of the chemistry of nitrosation based upon specific experimental conditions may provide a better understanding of how the subtle balance between oxidative and nitrosative stress may be involved in the etiology and control of various disease processes. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence Ridnour L. A. aut Thomas D. D. aut Mancardi D. aut Espey M. G. aut Miranda K. M. aut Paolocci N. aut Feelisch M. aut Fukuto J. aut Wink D. A. aut Biological Chemistry Walter de Gruyter 385/1(2004-01-05), 1-10 1431-6730 385:1<1 2004 385 bchm https://doi.org/10.1515/BC.2004.001 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2004.001 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ridnour L. A. aut NATIONALLICENCE 700 1- Thomas D. D. aut NATIONALLICENCE 700 1- Mancardi D. aut NATIONALLICENCE 700 1- Espey M. G. aut NATIONALLICENCE 700 1- Miranda K. M. aut NATIONALLICENCE 700 1- Paolocci N. aut NATIONALLICENCE 700 1- Feelisch M. aut NATIONALLICENCE 700 1- Fukuto J. aut NATIONALLICENCE 700 1- Wink D. A. aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 385/1(2004-01-05), 1-10 1431-6730 385:1<1 2004 385 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter