caa a22 4500 378916211 CHVBK 20180305123553.0 cr unu---uuuuu 161128e20040105xx s 000 0 eng 10.1515/BC.2004.002 doi (NATIONALLICENCE)gruyter-10.1515/BC.2004.002 Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity [Elektronische Daten] [P. K. M. Kim, B. S. Zuckerbraun, L. E. Otterbein, Y. Vodovotz, T. R. Billiar] Like many juggernauts in biology, the elusive nature of nitric oxide (NO) sprints through the fields, sometimes the savior, at other times the scimitar. In the liver, which is the metabolic center of the organism, hepatocytes and immune cells trade blows using the reactive diatomic molecule NO to induce cellular damage under toxic conditions. In response, hepatocytes can utilize several mechanisms of NO to their protective advantage by prohibiting the activation of programmed cell death, a.k.a. apoptosis. The balance of these effects in this reactive milieu set the stage for the homeostatic response to cellular injury that determines whether hepatocytes will live, die, or regenerate. Insights that we and others have gained from the liver under pathologic conditions of stress can be applied to the understanding of cellular death mechanisms in other organs and tissues. Copyright © 2004 by Walter de Gruyter GmbH & Co. KG Biochemistry nationallicence Molecular biology nationallicence Cellular biology nationallicence Kim P. K. M. aut Zuckerbraun B. S. aut Otterbein L. E. aut Vodovotz Y. aut Billiar T. R. aut Biological Chemistry Walter de Gruyter 385/1(2004-01-05), 11-15 1431-6730 385:1<11 2004 385 bchm https://doi.org/10.1515/BC.2004.002 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/BC.2004.002 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim P. K. M. aut NATIONALLICENCE 700 1- Zuckerbraun B. S. aut NATIONALLICENCE 700 1- Otterbein L. E. aut NATIONALLICENCE 700 1- Vodovotz Y. aut NATIONALLICENCE 700 1- Billiar T. R. aut NATIONALLICENCE 773 0- Biological Chemistry Walter de Gruyter 385/1(2004-01-05), 11-15 1431-6730 385:1<11 2004 385 bchm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter