caa a22 4500 378917242 CHVBK 20180305123556.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/JPM.2004.147 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2004.147 The use of recombinant factor VIIa in a primigravida with Glanzmann's thrombasthenia during delivery [Elektronische Daten] [Ahmet Kale, Gokhan Bayhan, Ahmet Yalinkaya, Murat Yayla] Glanzmann's thrombasthenia is an inherited hemorrhagic disorder characterized by a severe reduction in, or absence of, platelet aggregation in response to multiple physiologic agonists due to qualitative or quantitative abnormalities of platelet glycoprotein IIb-IIIa. Glanzmann's thrombasthenia is characterized by potentially major mucocutaneous bleeding and prolonged bleeding time. Platelet counts, platelet morphology, prothrombin, and activated thromboplastin times are all within normal ranges in patients with Glanzmann's thrombasthenia. Pregnancy and delivery are rare in Glanzmann thrombasthenia patients and have been associated with immediate postpartum hemorrhage. We describe the peripartum management of a 31-year-old primipara with Glanzmann's thrombasthenia who underwent spontaneous vaginal delivery. Four units of single-donor platelets, two units of packed red blood cells, 36 µg/kg recombinant human coagulation Factor VIIa (rFVIIa) were given during peripartum management. © Walter de Gruyter Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Glanzmann's thrombasthenia nationallicence platelet transfusion nationallicence postpartum hemorrhage nationallicence pregnancy nationallicence recombinant human coagulation factor VIIa (rFVIIa) nationallicence Kale Ahmet Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey aut Bayhan Gokhan Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey aut Yalinkaya Ahmet Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey aut Yayla Murat Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey aut Journal of Perinatal Medicine Walter de Gruyter 32/5(2004-09-01), 456-458 0300-5577 32:5<456 2004 32 jpme https://doi.org/10.1515/JPM.2004.147 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2004.147 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kale Ahmet Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Bayhan Gokhan Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Yalinkaya Ahmet Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Yayla Murat Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 32/5(2004-09-01), 456-458 0300-5577 32:5<456 2004 32 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter