caa a22 4500 378917307 CHVBK 20180305123556.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/JPM.2004.136 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2004.136 Mother-to-infant vertical transmission of transfusion transmitted virus in South China [Elektronische Daten] [Xiao Xin, Zhou Xiaoguang, Zhu Ninghu, Luo Youtong, Xu Liumei, Zhou Boping] A nested PCR was used to detect TTV DNA in serum from 490 mother-infant pairs to determine the rate of vertical transmission of TTV in Guangzhou City, P.R. China. TTV DNA was positive in 87 mothers and 12 of their babies, giving a prevalence of 17.8% in pregnant women and a mother-to-child transmission rate of 13.8%. In eight mother-infant pairs, TTV DNA nucleotide sequences from the mothers and their corresponding infants were identical. The homology of Guangzhou TTV and Japanese TTV ranged from 85.3%-98.2% at nucleotide level. TTV infection is common in pregnant women in South China and vertical transmission can occur. Guangzhou's and Japanese TTV isolates belong to the same genotype. © Walter de Gruyter Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Genetics nationallicence infant nationallicence nested polymerase chain reaction nationallicence pregnancy nationallicence transfusion transmitted virus nationallicence vertical transmission nationallicence Xin Xiao Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, P.R. China aut Xiaoguang Zhou Department of Neonatology, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou, P.R. China aut Ninghu Zhu Maternal and Children's Health Hospital of Guangdong Province, Guangzhou, P.R. China aut Youtong Luo Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, P.R. China aut Liumei Xu Shenzhen Research Institute of Hepatology, Shenzhen, P.R. China aut Boping Zhou Shenzhen Research Institute of Hepatology, Shenzhen, P.R. China aut Journal of Perinatal Medicine Walter de Gruyter 32/5(2004-09-01), 404-406 0300-5577 32:5<404 2004 32 jpme https://doi.org/10.1515/JPM.2004.136 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2004.136 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xin Xiao Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, P.R. China aut NATIONALLICENCE 700 1- Xiaoguang Zhou Department of Neonatology, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou, P.R. China aut NATIONALLICENCE 700 1- Ninghu Zhu Maternal and Children's Health Hospital of Guangdong Province, Guangzhou, P.R. China aut NATIONALLICENCE 700 1- Youtong Luo Perinatal Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, P.R. China aut NATIONALLICENCE 700 1- Liumei Xu Shenzhen Research Institute of Hepatology, Shenzhen, P.R. China aut NATIONALLICENCE 700 1- Boping Zhou Shenzhen Research Institute of Hepatology, Shenzhen, P.R. China aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 32/5(2004-09-01), 404-406 0300-5577 32:5<404 2004 32 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter