Evaluation of second trimester maternal serum screening for Down's Syndrome using the Spiegelhalter-Knill-Jones (S-KJ) approach
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 378917315 | ||
| 003 | CHVBK | ||
| 005 | 20180305123556.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 161128e20040901xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1515/JPM.2004.137 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/JPM.2004.137 | ||
| 245 | 0 | 0 | |a Evaluation of second trimester maternal serum screening for Down's Syndrome using the Spiegelhalter-Knill-Jones (S-KJ) approach |h [Elektronische Daten] |c [Hsiao-Lin Hwa, Ming-Fang Yen, Fon-Jou Hsieh, Tsang-Ming Ko, Tony Hsiu-Hsi Chen] |
| 520 | 3 | |a Aims: Risk estimation for Down's syndrome in antenatal serum screening with maternal age and multiple serum biomarkers is usually complicated and computationally intensive. We have developed a simple scoring system using the Spiegelhalter-Knill-Jones approach, which was based on Bayesian theorem and the logistic regression model. Methods: A prospective data set with 3842 singleton pregnancies including 6 affected pregnancies served as "trained data”. Maternal age, maternal serum alpha-fetoprotein and human chorionic gonadotrophin levels of each pregnant woman were adopted as the predictors to establish the scoring model using the S-KJ approach. Model validation was undertaken using a receiver operating characteristics (ROC) curve with another 3050 singleton pregnancies including 4 affected pregnancies ("validated data”). Results: For the trained data the sensitivity and specificity of the scoring system at cut-off value of 1:250 was 66.7% and 92.6%, respectively. For the validated data the sensitivity and specificity at the same cut-off point was 75% and 92.2%, respectively. The area under the ROC curve of the trained and validated data was 76.96% (95% CI: 51.80-100%), and 94.07% (95% CI: 84.47-100%), respectively. Conclusions: The S-KJ scoring system has been demonstrated to be a simple, and efficient method for the risk estimation of Down's syndrome. This system can be applied to other antenatal serum screening systems. | |
| 540 | |a © Walter de Gruyter | ||
| 690 | 7 | |a Human reproduction, growth & development |2 nationallicence | |
| 690 | 7 | |a Gynaecology & obstetrics |2 nationallicence | |
| 690 | 7 | |a Paediatric medicine |2 nationallicence | |
| 690 | 7 | |a Antenatal serum screening |2 nationallicence | |
| 690 | 7 | |a Bayesian theorem |2 nationallicence | |
| 690 | 7 | |a Down's syndrome |2 nationallicence | |
| 690 | 7 | |a Logistic regression |2 nationallicence | |
| 690 | 7 | |a Spiegelhalter-Knill-Jones (S-KJ) approach |2 nationallicence | |
| 700 | 1 | |a Hwa |D Hsiao-Lin |u Department of Obstetrics and Gynecology, National Taiwan, University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taiwan |4 aut | |
| 700 | 1 | |a Yen |D Ming-Fang |u Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taiwan |4 aut | |
| 700 | 1 | |a Hsieh |D Fon-Jou |u Department of Obstetrics and Gynecology, National Taiwan, University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taiwan |4 aut | |
| 700 | 1 | |a Ko |D Tsang-Ming |u Department of Obstetrics and Gynecology, National Taiwan, University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taiwan |4 aut | |
| 700 | 1 | |a Chen |D Tony Hsiu-Hsi |u Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taiwan |4 aut | |
| 773 | 0 | |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/5(2004-09-01), 407-412 |x 0300-5577 |q 32:5<407 |1 2004 |2 32 |o jpme | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/JPM.2004.137 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/JPM.2004.137 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hwa |D Hsiao-Lin |u Department of Obstetrics and Gynecology, National Taiwan, University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yen |D Ming-Fang |u Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hsieh |D Fon-Jou |u Department of Obstetrics and Gynecology, National Taiwan, University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ko |D Tsang-Ming |u Department of Obstetrics and Gynecology, National Taiwan, University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chen |D Tony Hsiu-Hsi |u Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Perinatal Medicine |d Walter de Gruyter |g 32/5(2004-09-01), 407-412 |x 0300-5577 |q 32:5<407 |1 2004 |2 32 |o jpme | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||