caa a22 4500 378917323 CHVBK 20180305123556.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/JPM.2004.145 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2004.145 Amniotic cavity cultures, blood cultures, and surface swabs in preterm infants - useful tools for the management of early-onset sepsis? [Elektronische Daten] [Angelika Berger, Armin Witt, Nadja Haiden, Veronika Kretzer, Georg Heinze, Arnold Pollak] Aims: To evaluate the potential benefit of amniotic fluid and amniotic/placental membrane cultures for the management of early-onset sepsis in preterm infants. Methods: The results of amniotic cavity cultures obtained during cesarean section and of peripheral blood cultures and surface swabs obtained from the preterm infant at the time of admission were analyzed with respect to the diagnosis of clinical sepsis in 221 preterm infants <34 weeks of gestation. Results: 136 (61.5%) patients had negative amniotic cavity culture results or growth of contaminants, 56 (25.3%) had growth of Ureaplasma urealyticum, and 29 (13.1%) of other pathogens. The corresponding numbers for surface swabs were 82.8%, 11.6%, and 5.6%. A positive blood culture was found in only two neonates. Fifty-four patients (24.4%) had clinical early-onset sepsis. Patients with amniotic cavity culture results that were positive for other pathogens were significantly more likely to experience clinical sepsis than patients with negative culture results (51.7% vs 15.1%, OR 6.1, p < 0.0001). Regarding surface swabs, this correlation did not reach statistical significance. Conclusion: The strong association between positive amniotic cavity culture results and clinical early-onset sepsis supports the existence of a causal relation and provides evidence for the potential value of amniotic and/or placental membrane sampling in the management of early-onset sepsis in preterm infants. Surface swabs add no additional information and hence should not be performed routinely. © Walter de Gruyter Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Amniotic cavity culture nationallicence blood culture nationallicence early-onset sepsis nationallicence preterm infant nationallicence surface swab nationallicence Berger Angelika Department of Pediatrics, Division of Neonatology and Intensive Care, University Hospital Vienna, Austria aut Witt Armin Department of Obstetrics and Gynecology, University Hospital Vienna, Austria aut Haiden Nadja Department of Pediatrics, Division of Neonatology and Intensive Care, University Hospital Vienna, Austria aut Kretzer Veronika Department of Pediatrics, Division of Neonatology and Intensive Care, University Hospital Vienna, Austria aut Heinze Georg Department of Medical Computer Sciences, University Hospital Vienna, Austria aut Pollak Arnold Department of Pediatrics, Division of Neonatology and Intensive Care, University Hospital Vienna, Austria aut Journal of Perinatal Medicine Walter de Gruyter 32/5(2004-09-01), 446-452 0300-5577 32:5<446 2004 32 jpme https://doi.org/10.1515/JPM.2004.145 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2004.145 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berger Angelika Department of Pediatrics, Division of Neonatology and Intensive Care, University Hospital Vienna, Austria aut NATIONALLICENCE 700 1- Witt Armin Department of Obstetrics and Gynecology, University Hospital Vienna, Austria aut NATIONALLICENCE 700 1- Haiden Nadja Department of Pediatrics, Division of Neonatology and Intensive Care, University Hospital Vienna, Austria aut NATIONALLICENCE 700 1- Kretzer Veronika Department of Pediatrics, Division of Neonatology and Intensive Care, University Hospital Vienna, Austria aut NATIONALLICENCE 700 1- Heinze Georg Department of Medical Computer Sciences, University Hospital Vienna, Austria aut NATIONALLICENCE 700 1- Pollak Arnold Department of Pediatrics, Division of Neonatology and Intensive Care, University Hospital Vienna, Austria aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 32/5(2004-09-01), 446-452 0300-5577 32:5<446 2004 32 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter