caa a22 4500 378917331 CHVBK 20180305123556.0 cr unu---uuuuu 161128e20040901xx s 000 0 eng 10.1515/JPM.2004.139 doi (NATIONALLICENCE)gruyter-10.1515/JPM.2004.139 Maternal and fetal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3, and their relationship to fetal acidosis at delivery [Elektronische Daten] [Sharon M. Cooley, Jennifer C. Donnelly, Michael P. Geary, Charles H. Rodeck, Peter C. Hindmarsh] Objective: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and in fetal cord blood at delivery. Methods: Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, Illinois, USA), with p < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking and in fetal blood by cord blood analysis at delivery. Cord pH was also recorded. Results: There was no significant correlation between maternal IGF-1, IGF-2, or IGFBP-3 levels and fetal acidosis. However, a significant correlation does exist between cord IGF-1 levels and fetal acidosis. Conclusion: Fetal cord IGF-1 has a significant correlation with fetal acidosis at delivery. © Walter de Gruyter Human reproduction, growth & development nationallicence Gynaecology & obstetrics nationallicence Paediatric medicine nationallicence Fetal acidosis nationallicence fetal distress nationallicence insulin-like growth factor nationallicence insulin-like growth factor binding protein nationallicence Cooley Sharon M. Obstetric Research Department, Rotunda Hospital, Dublin, Ireland aut Donnelly Jennifer C. aut Geary Michael P. aut Rodeck Charles H. aut Hindmarsh Peter C. aut Journal of Perinatal Medicine Walter de Gruyter 32/5(2004-09-01), 418-421 0300-5577 32:5<418 2004 32 jpme https://doi.org/10.1515/JPM.2004.139 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/JPM.2004.139 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cooley Sharon M. Obstetric Research Department, Rotunda Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Donnelly Jennifer C. aut NATIONALLICENCE 700 1- Geary Michael P. aut NATIONALLICENCE 700 1- Rodeck Charles H. aut NATIONALLICENCE 700 1- Hindmarsh Peter C. aut NATIONALLICENCE 773 0- Journal of Perinatal Medicine Walter de Gruyter 32/5(2004-09-01), 418-421 0300-5577 32:5<418 2004 32 jpme CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter