caa a22 4500 378917501 CHVBK 20180305123557.0 cr unu---uuuuu 161128e20041101xx s 000 0 eng 10.1515/CCLM.2004.247 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.247 Hair analysis in toxicology [Elektronische Daten] [Marion Villain, Vincent Cirimele, Pascal Kintz] Morphological, serological and chemical examination of human hair for medical purposes was initiated some decades ago. In the 1960s and 1970s, hair analysis was used to evaluate exposure to toxic heavy metals. At this time, examination of hair for organic substances, especially drugs, was not possible because analytical methods were not sensitive enough. Since the early 1980s, the development of highly sensitive and specific assay methods such as radioimmunoassay or gas chromatography/mass spectrometry has permitted the analysis of organic substances trapped in hair. This, theoretically, offered the possibility of revealing an individual's recent history of drug exposure beginning at sampling day and dating back over a period of weeks or months. The present review aims to summarise the various applications that have been published. © Walter de Gruyter Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence abuse nationallicence chromatography nationallicence drugs nationallicence exposure nationallicence hair analysis nationallicence mass spectrometry nationallicence toxicology nationallicence Villain Marion Laboratoire de Toxicologie, Institut de Médecine Légale, Strasbourg, France aut Cirimele Vincent Laboratoire de Toxicologie, Institut de Médecine Légale, Strasbourg and Laboratoire ChemTox, Rue Geiler de Kaysersberg, Illkirch, France aut Kintz Pascal Laboratoire de Toxicologie, Institut de Médecine Légale, Strasbourg, France aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/11(2004-11-01), 1265-1272 1434-6621 42:11<1265 2004 42 cclm https://doi.org/10.1515/CCLM.2004.247 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.247 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Villain Marion Laboratoire de Toxicologie, Institut de Médecine Légale, Strasbourg, France aut NATIONALLICENCE 700 1- Cirimele Vincent Laboratoire de Toxicologie, Institut de Médecine Légale, Strasbourg and Laboratoire ChemTox, Rue Geiler de Kaysersberg, Illkirch, France aut NATIONALLICENCE 700 1- Kintz Pascal Laboratoire de Toxicologie, Institut de Médecine Légale, Strasbourg, France aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/11(2004-11-01), 1265-1272 1434-6621 42:11<1265 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter