caa a22 4500 378917536 CHVBK 20180305123557.0 cr unu---uuuuu 161128e20041101xx s 000 0 eng 10.1515/CCLM.2004.248 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.248 Oral fluid as a diagnostic tool [Elektronische Daten] [Robin E. Choo, Marilyn A. Huestis] Technological advances over the past decades have enabled oral fluid to expand its usefulness in the diagnosis of disease, prediction of disease progression, monitoring of therapeutic drug levels and detection of illicit drugs. The easy non-invasive nature of collection and the relationship between oral fluid and plasma levels make oral fluid a valuable clinical tool. This review describes advances over the past 5 years in the area of oral fluid as a diagnostic tool, its use in therapeutic and illicit drug monitoring, including proposed guidelines for cut-off values, and methods of collection. © Walter de Gruyter Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence illicit drugs nationallicence oral fluid nationallicence saliva nationallicence therapeutic drug monitoring nationallicence Choo Robin E. Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute of Drug Abuse, National Institute of Health, Baltimore, MD, USA aut Huestis Marilyn A. Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute of Drug Abuse, National Institute of Health, Baltimore, MD, USA aut Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/11(2004-11-01), 1273-1287 1434-6621 42:11<1273 2004 42 cclm https://doi.org/10.1515/CCLM.2004.248 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.248 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Choo Robin E. Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute of Drug Abuse, National Institute of Health, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Huestis Marilyn A. Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute of Drug Abuse, National Institute of Health, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/11(2004-11-01), 1273-1287 1434-6621 42:11<1273 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter