caa a22 4500 378917544 CHVBK 20180305123557.0 cr unu---uuuuu 161128e20041101xx s 000 0 eng 10.1515/CCLM.2004.243 doi (NATIONALLICENCE)gruyter-10.1515/CCLM.2004.243 Mitchell Philip B. 1. School of Psychiatry, University of New South Wales and Black Dog Institute, Sydney, Australia Therapeutic drug monitoring of non-tricyclic antidepressant drugs [Elektronische Daten] [Philip B. Mitchell] Therapeutic drug monitoring (TDM) of many of the tricyclic antidepressants (TCAs) has been demonstrated to be of clear clinical value. This article reviews studies of TDM for the selective serotonin reuptake inhibitors (SSRIs) and other non-tricyclic antidepressants such as venlafaxine, nefazodone, trazodone, mianserin and bupropion. No definitive therapeutic concentrations have been demonstrated for these agents, nor have levels indicative of toxicity been reported. The major benefit of TDM for these agents would appear to be in the assessment of the apparently treatment-refractory depressed patient, to determine whether such lack of response is related to inadequate levels that would suggest either poor compliance, ultra-rapid metabolism, or drug interactions leading to induction of metabolising enzymes. Potential future applications of TDM, in conjunction with genotyping of cytochrome P450 enzymes and pharmacogenomic evaluations, are discussed. © Walter de Gruyter Medical equipment & techniques nationallicence Medical diagnosis nationallicence Diseases & disorders nationallicence cytochrome P450 nationallicence non-tricyclic antidepressant nationallicence selective serotonin reuptake inhibitors (SSRIs) nationallicence therapeutic drug monitoring nationallicence venlafaxine nationallicence Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/11(2004-11-01), 1212-1218 1434-6621 42:11<1212 2004 42 cclm https://doi.org/10.1515/CCLM.2004.243 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1515/CCLM.2004.243 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Mitchell Philip B. 1. School of Psychiatry, University of New South Wales and Black Dog Institute, Sydney, Australia NATIONALLICENCE 773 0- Clinical Chemistry and Laboratory Medicine Walter de Gruyter 42/11(2004-11-01), 1212-1218 1434-6621 42:11<1212 2004 42 cclm CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter