Remodelling of Ca2+ homeostasis in type I cortical astrocytes by hypoxia: evidence for association with Alzheimer's disease
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| 024 | 7 | 0 | |a 10.1515/BC.2004.023 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1515/BC.2004.023 | ||
| 245 | 0 | 0 | |a Remodelling of Ca2+ homeostasis in type I cortical astrocytes by hypoxia: evidence for association with Alzheimer's disease |h [Elektronische Daten] |c [C. Peers, I. F. Smith, J. P. Boyle, H. A. Pearson] |
| 520 | 3 | |a Sustained central hypoxia predisposes individuals to dementias such as Alzheimer's disease, in which cells are destroyed in part by disruption of Ca2+ homeostasis. Here, we show that exposure of astrocytes to hypoxia in vitro causes inhibition of plasmalemmal Na+/Ca2+ exchange and excessive mitochondrial Ca2q loading. Both factors disrupt normal agonist-evoked Ca2+ signalling. Moreover, hypoxia increases the levels of presenilin-1, a major component of a key enzyme involved in Alzheimers disease. Inhibition of this enzyme partially reverses the effects of hypoxia on Ca2+ signalling. These findings provide an initial cellular basis for understanding the clinical association of hypoxia with Alzheimers disease. | |
| 540 | |a Copyright © 2004 by Walter de Gruyter GmbH & Co. KG | ||
| 690 | 7 | |a Biochemistry |2 nationallicence | |
| 690 | 7 | |a Molecular biology |2 nationallicence | |
| 690 | 7 | |a Cellular biology |2 nationallicence | |
| 700 | 1 | |a Peers |D C. |4 aut | |
| 700 | 1 | |a Smith |D I. F. |4 aut | |
| 700 | 1 | |a Boyle |D J. P. |4 aut | |
| 700 | 1 | |a Pearson |D H. A. |4 aut | |
| 773 | 0 | |t Biological Chemistry |d Walter de Gruyter |g 385/3-4(2004-04-13), 285-289 |x 1431-6730 |q 385:3-4<285 |1 2004 |2 385 |o bchm | |
| 856 | 4 | 0 | |u https://doi.org/10.1515/BC.2004.023 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1515/BC.2004.023 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Peers |D C. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Smith |D I. F. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Boyle |D J. P. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pearson |D H. A. |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biological Chemistry |d Walter de Gruyter |g 385/3-4(2004-04-13), 285-289 |x 1431-6730 |q 385:3-4<285 |1 2004 |2 385 |o bchm | ||
| 900 | 7 | |b CC0 |u http://creativecommons.org/publicdomain/zero/1.0 |2 nationallicence | |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||