Chemistry for the synthesis of nucleobase-modified peptide nucleic acid
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| 024 | 7 | 0 | |a 10.1351/pac200476071591 |2 doi |
| 035 | |a (NATIONALLICENCE)gruyter-10.1351/pac200476071591 | ||
| 245 | 0 | 0 | |a Chemistry for the synthesis of nucleobase-modified peptide nucleic acid |h [Elektronische Daten] |c [R. H. E. Hudson, R. D. Viirre, Y. H. Liu, F. Wojciechowski, A. K. Dambenieks] |
| 520 | 3 | |a Peptide nucleic acid (PNA) presents a versatile scaffold for chemical modifications that may benefit its solubility and hybridization properties, conjugation chemistry, cell membrane permeability, and so forth. We have employed straightforward chemical methods for the synthesis of PNA monomers containing C5-or C6-modified pyrimidines.The C5-modified pyrimidines are based on 5-hydroxymethyl-uracil or cytosine, or are achieved by cross-coupling from the 5-iodonucleobase derivatives, while C6 modifications are accessed from 6-carboxyuracil (orotic acid). We have also developed an on-resin activation/conversion of uracil-containing PNA oligomers to N4-cytosine-containing derivatives. | |
| 540 | |a © 2013 Walter de Gruyter GmbH, Berlin/Boston | ||
| 700 | 1 | |a Hudson |D R. H. E. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | |
| 700 | 1 | |a Viirre |D R. D. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | |
| 700 | 1 | |a Liu |D Y. H. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | |
| 700 | 1 | |a Wojciechowski |D F. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | |
| 700 | 1 | |a Dambenieks |D A. K. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | |
| 773 | 0 | |t Pure and Applied Chemistry |d De Gruyter |g 76/7-8(2004-01-01), 1591-1598 |x 0033-4545 |q 76:7-8<1591 |1 2004 |2 76 |o pac | |
| 856 | 4 | 0 | |u https://doi.org/10.1351/pac200476071591 |q text/html |z Onlinezugriff via DOI |
| 908 | |D 1 |a research article |2 jats | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1351/pac200476071591 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hudson |D R. H. E. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Viirre |D R. D. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Y. H. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wojciechowski |D F. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dambenieks |D A. K. |u Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Pure and Applied Chemistry |d De Gruyter |g 76/7-8(2004-01-01), 1591-1598 |x 0033-4545 |q 76:7-8<1591 |1 2004 |2 76 |o pac | ||
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| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-gruyter | ||