caa a22 4500 378921762 CHVBK 20180305123607.0 cr unu---uuuuu 161128e20040101xx s 000 0 eng 10.1351/pac200476071321 doi (NATIONALLICENCE)gruyter-10.1351/pac200476071321 Polymeric micelles for oral drug delivery: Why and how [Elektronische Daten] [M. F. Francis, Mariana Cristea, F. M. Winnik] The oral delivery of drugs is regarded as the optimal means for achieving therapeutic effects owing to increased patient compliance. Unfortunately, the oral delivery route is beset with problems such as gastrointestinal (GI) destruction of labile molecules, low levels of macromolecular absorption, etc. To reduce the impact of digestive enzymes and to ensure the absorption of bioactive agents in an unaltered form, molecules may be incorporated into microparticulate carriers. Many approaches to achieve the oral absorption of a wide variety of drugs are currently under investigation. Among the different polymer-based drug delivery systems, polymeric micelles represent a promising delivery vehicle especially intended for poorly water-soluble pharmaceutical active ingredients in order to improve their oral bioavailability. Recent findings of a dextran-based polymeric micelle study for solubilization of a highly lipophilic drug, cyclosporin A (CsA), will be discussed. © 2013 Walter de Gruyter GmbH, Berlin/Boston Francis M. F. Faculty of Pharmacy, University of Montreal, C.P. 6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Department of Chemistry, University of Montreal, C.P.6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Petru Poni Institute of Macromolecular Chemistry, Iasi 6600, Romania aut Cristea Mariana Faculty of Pharmacy, University of Montreal, C.P. 6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Department of Chemistry, University of Montreal, C.P.6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Petru Poni Institute of Macromolecular Chemistry, Iasi 6600, Romania aut Winnik F. M. Faculty of Pharmacy, University of Montreal, C.P. 6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Department of Chemistry, University of Montreal, C.P.6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Petru Poni Institute of Macromolecular Chemistry, Iasi 6600, Romania aut Pure and Applied Chemistry De Gruyter 76/7-8(2004-01-01), 1321-1335 0033-4545 76:7-8<1321 2004 76 pac https://doi.org/10.1351/pac200476071321 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476071321 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Francis M. F. Faculty of Pharmacy, University of Montreal, C.P. 6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Department of Chemistry, University of Montreal, C.P.6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Petru Poni Institute of Macromolecular Chemistry, Iasi 6600, Romania aut NATIONALLICENCE 700 1- Cristea Mariana Faculty of Pharmacy, University of Montreal, C.P. 6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Department of Chemistry, University of Montreal, C.P.6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Petru Poni Institute of Macromolecular Chemistry, Iasi 6600, Romania aut NATIONALLICENCE 700 1- Winnik F. M. Faculty of Pharmacy, University of Montreal, C.P. 6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Department of Chemistry, University of Montreal, C.P.6128 Succ. Centreville, Montreal, Quebec H3C 3J7, Canada; Petru Poni Institute of Macromolecular Chemistry, Iasi 6600, Romania aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/7-8(2004-01-01), 1321-1335 0033-4545 76:7-8<1321 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter