caa a22 4500 37892186X CHVBK 20180305123607.0 cr unu---uuuuu 161128e20040101xx s 000 0 eng 10.1351/pac200476071525 doi (NATIONALLICENCE)gruyter-10.1351/pac200476071525 Ribozymes that use redox cofactors [Elektronische Daten] [S. Tsukiji, K. Ramaswamy, H. Suga] This review summarizes the history and most recent advances in aptamers and ribozymes that bind and use redox (reduction-oxidation) cofactors. Redox reactions, catalyzed by protein enzymes in an extant world, play a central role in the metabolism of numerous biological molecules in the living organisms. The burden of catalyzing these reactions in a pre-protein-based world (i.e., the hypothesized RNA World) could have been borne by RNA molecules. To this end, we raise a fundamental question: can RNA accelerate the redox chemical transformation? We hope that this article will be able to shed light on this intriguing question. © 2013 Walter de Gruyter GmbH, Berlin/Boston Tsukiji S. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan aut Ramaswamy K. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan aut Suga H. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan aut Pure and Applied Chemistry De Gruyter 76/7-8(2004-01-01), 1525-1536 0033-4545 76:7-8<1525 2004 76 pac https://doi.org/10.1351/pac200476071525 text/html Onlinezugriff via DOI 1 research article jats NATIONALLICENCE 856 40 https://doi.org/10.1351/pac200476071525 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsukiji S. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan aut NATIONALLICENCE 700 1- Ramaswamy K. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan aut NATIONALLICENCE 700 1- Suga H. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan aut NATIONALLICENCE 773 0- Pure and Applied Chemistry De Gruyter 76/7-8(2004-01-01), 1525-1536 0033-4545 76:7-8<1525 2004 76 pac CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-gruyter